A new potential specifically marks the sensory thalamus in anaesthetised patients |
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| Affiliation: | 1. Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy;2. Department of Mechanical and Aerospace Engineering, Sapienza University of Rome, Italy;3. IRCCS Fondazione Don Carlo Gnocchi, 50143 Florence, Italy;4. IRCCS Fondazione Don Carlo Gnocchi, 20121 Milan, Italy;5. Department of Geriatrics, Neurosciences and Orthopaedics, Università Cattolica del Sacro Cuore, 00168 Rome, Italy;6. Department of Economics, Engineering, Society and Business Organization (DEIM), University of Tuscia, 01100 Viterbo, Italy;1. Department of Neurosurgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan;2. National Hospital Organization Shibukawa Medical Center, Shibukawa, Japan;1. Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois, USA;2. Section on Movement Disorders, Department of Neurology, Rush University Medical Center, Chicago, Illinois, USA;1. Division of Neurosurgery, University of British Columbia, Vancouver, Canada;2. Department of Stereotactic and Functional Neurosurgery, Heinrich-Heine University, Düsseldorf, Germany |
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| Abstract: | ObjectiveDuring deep brain stimulation (DBS) surgery, we analysed somatosensory evoked potentials (SSEPs) using microelectrode recordings (MERs) in patients under general anaesthesia.MethodsWe obtained MERs from 5 patients with refractory epilepsy. Off-line analysis isolated local field potentials (LFPs, 2–200 Hz) and high frequency components (HFCs, 0.5–5 kHz). Trajectories were reconstructed off-line.ResultsThe ventral caudate (V.c.) nucleus was most frequently recorded from (171 mm). Very high frequency oscillations (VHFOs) were recorded up to 8 mm in length from all 4 electrodes but were most frequently recorded from the V.c. The properties of VHFOs were similar among all nuclei (frequency >1500 Hz, amplitude ∼3 µV, starting time ∼14 ms, duration 8–9 ms). Consecutive recordings did not show any synchronization or propagation, but a new kind of potential (high frequency oscillation, HFO) appeared abruptly inside the V.c. (frequency = 848 ± 66 Hz, amplitude = 5.2 ± 1.8 µV starting at 17.7 ± 0.5 ms, spanning 3.4 ± 0.3 ms).ConclusionsVHFOs are widely extending and cannot be ascribed to the V.c. HFOs in patients under general anaesthesia can serve as a landmark to identify the V.c. in thalamic DBS surgery.SignificanceThalamic processing involves nuclei other than the V.c, and HFO can be used to improve DBS surgery. |
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| Keywords: | Centromedian Deep brain stimulation High frequency oscillations Microelectrode recordings Somatosensory evoked potentials Ventral caudal Ce" },{" #name" :" keyword" ," $" :{" id" :" k0040" }," $$" :[{" #name" :" text" ," _" :" centromedian nucleus DBS" },{" #name" :" keyword" ," $" :{" id" :" k0050" }," $$" :[{" #name" :" text" ," _" :" deep brain stimulation DDNN" },{" #name" :" keyword" ," $" :{" id" :" k0060" }," $$" :[{" #name" :" text" ," _" :" dorsal nuclei CWT" },{" #name" :" keyword" ," $" :{" id" :" k0070" }," $$" :[{" #name" :" text" ," _" :" continuous wavelet transform FFT" },{" #name" :" keyword" ," $" :{" id" :" k0080" }," $$" :[{" #name" :" text" ," _" :" fast Fourier transform HFC" },{" #name" :" keyword" ," $" :{" id" :" k0090" }," $$" :[{" #name" :" text" ," _" :" high frequency component HFO" },{" #name" :" keyword" ," $" :{" id" :" k0100" }," $$" :[{" #name" :" text" ," _" :" high frequency oscillation, LFP, local field potential MERs" },{" #name" :" keyword" ," $" :{" id" :" k0110" }," $$" :[{" #name" :" text" ," _" :" microelectrode recordings MRI" },{" #name" :" keyword" ," $" :{" id" :" k0120" }," $$" :[{" #name" :" text" ," _" :" magnetic resonance imaging SSEP" },{" #name" :" keyword" ," $" :{" id" :" k0130" }," $$" :[{" #name" :" text" ," _" :" somatosensory evoked potentials SW" },{" #name" :" keyword" ," $" :{" id" :" k0140" }," $$" :[{" #name" :" text" ," _" :" Schaltenbrand-Wahren V.c." },{" #name" :" keyword" ," $" :{" id" :" k0150" }," $$" :[{" #name" :" text" ," _" :" ventral caudate nucleus VHFO" },{" #name" :" keyword" ," $" :{" id" :" k0160" }," $$" :[{" #name" :" text" ," _" :" very high frequency oscillation V.im." },{" #name" :" keyword" ," $" :{" id" :" k0170" }," $$" :[{" #name" :" text" ," _" :" ventrointermedial nucleus V.o." },{" #name" :" keyword" ," $" :{" id" :" k0180" }," $$" :[{" #name" :" text" ," _" :" ventral oralis nucleus |
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