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Mycobacterium chelonae cutaneous infection in a patient with mixed connective tissue disease
Authors:Renan Lage  Danilo Guerreiro Zeolo Biccigo  Felipe Borba Calixto Santos  Erica Chimara  Elisangela Samartin Pegas Pereira  Adilson da Costa
Affiliation:1.Pontifícia Universidade Católica de Campinas (PUC Campinas) – Campinas (SP), Brazil.;2.Instituto Adolfo Lutz – São Paulo (SP), Brazil.
Abstract:Around 50 mycobacteria species cause human disease. Immunosuppressive statespredispose to non-tuberculous mycobaterium infection, such as Mycobacterium chelonae:AFB, non-tuberculous, fast growth of low virulence and uncommon as a human pathogen.It may compromise the skin and soft tissues, lungs, lymph nodes and there is also adisseminated presentation. The diagnosis involves AFB identification and culture onAgar and Lowenstein-Jensen medium base. A 41-year-old female with MCTD (LESpredominance) is reported, presenting painless nodules in the right forearm. Shedenied local trauma. Immunosuppressed with prednisone and cyclophosphamide for 24months. Lesion biopsy has demonstrated positive bacilloscopy (Ziehl-Neelsen stain)and M.chelonae in culture (Lowenstein-Jensen medium base), therefore clarithromycintreatment has been started (best therapy choice in the literature).
Keywords:Clarithromycin   Immunosuppression   Mixed connective tissue disease   Mycobacterium chelonae   Mycobacterium fortuitum   Nontuberculous mycobacteria   Prednisone   Skin   Virulence
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