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Prevalence and correlates of mild cognitive impairment among diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging results
Affiliation:1. Department of Neurosciences, Shiley-Marcos Alzheimer''s Disease Research Center, UC San Diego, San Diego, CA, USA;2. Department of Healthcare Sciences, Wayne State University, Institute of Gerontology, Detroit, MI, USA;3. Department of Psychology, University of Miami, Miami, FL, USA;4. University of Texas Health Science Center, Houston, TX, USA;5. Department of Biostatistics, University of North Carolina, Collaborative Studies Coordinating Center, Chapel Hill, NC, USA;6. Department of Psychology, San Diego State University, San Diego, CA, USA;7. Institute for Minority Health Research, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA;8. Albert Einstein, College of Medicine, New York, NY, USA;9. Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle WA, USA;10. Department of Neurology, University of Miami, Miami, FL, USA;11. Department of Psychiatry and Behavioral Sciences, Rush Alzheimer''s Disease Center, Rush University Medical Center, Chicago, IL, USA;12. RTI International, Research Triangle Park, NC, USA;13. Department of Neurology, Alzheimer''s Disease Center, UC Davis, Sacramento, CA, USA;1. Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China;2. Department of Health Statistics, School of Public Health, Fudan University, Shanghai, China;3. Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA;1. Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA;2. Stanford Geriatric Education Center, Stanford University School of Medicine, Stanford, CA, USA;1. Dementias Platform UK, Department of Psychiatry, University of Oxford Warneford Hospital, Oxford, UK;2. Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), Department of Psychology, University of Edinburgh, Edinburgh, UK;3. Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK;4. Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK;5. Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK;6. UK Biobank, Cheadle, Stockport, UK;7. Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, Denmark Hill, London, UK;8. NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK;9. University of Edinburgh Centre for Genomic and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK;1. Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA;2. Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA;1. Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins, Baltimore, MD, USA;2. Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute, Department of Pharmacy, University of Washington, Seattle, WA, USA;3. Pharmaceutical Economics and Policy, School of Pharmacy, Leonard D. Schaeffer Center for Health Policy and Economics, University of Southern California, Los Angeles, CA, USA;4. Leonard D. Schaeffer Center for Health Policy & Economics, University of Southern California, Los Angeles, CA, USA;5. Keck School of Medicine, University of Southern California, Los Angeles, CA, USA;6. Price School of Public Policy, Leonard D. Schaeffer Center for Health Policy and Economics, University of Southern California, Los Angeles, CA, USA;1. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia;2. Department of Genomic Medicine, Royal Melbourne Hospital, Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC, Australia;3. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA;4. Collaborative Genomics Group, Centre of Excellence for Alzheimer''s Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia;5. School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia;6. The Florey Institute, University of Melbourne, Parkville, Victoria, Australia
Abstract:IntroductionWe estimated the prevalence and correlates of mild cognitive impairment (MCI) among middle-aged and older diverse Hispanics/Latinos.MethodsMiddle-aged and older diverse Hispanics/Latinos enrolled (n = 6377; 50–86 years) in this multisite prospective cohort study were evaluated for MCI using the National Institute on Aging–Alzheimer's Association diagnostic criteria.ResultsThe overall MCI prevalence was 9.8%, which varied between Hispanic/Latino groups. Older age, high cardiovascular disease (CVD) risk, and elevated depressive symptoms were significant correlates of MCI prevalence. Apolipoprotein E4 (APOE) and APOE2 were not significantly associated with MCI.DiscussionMCI prevalence varied among Hispanic/Latino backgrounds, but not as widely as reported in the previous studies. CVD risk and depressive symptoms were associated with increased MCI, whereas APOE4 was not, suggesting alternative etiologies for MCI among diverse Hispanics/Latinos. Our findings suggest that mitigating CVD risk factors may offer important pathways to understanding and reducing MCI and possibly dementia among diverse Hispanics/Latinos.
Keywords:Epidemiology  Mild cognitive impairment  Alzheimer's disease  Dementia  Neuroepidemiology  Cognitive function  Cognitive decline  Neuropsychology  Hispanics  Latinos  Hispanics/Latinos  Population neuroscience
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