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Failure to detect an association between self-reported traumatic brain injury and Alzheimer's disease neuropathology and dementia |
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| Institution: | 1. Department of Neuroscience, Monash University, 99 Commercial Road, Melbourne, VIC, Australia;2. Department of Medicine (Royal Melbourne Hospital), The University of Melbourne, Royal Parade, Parkville, VIC, Australia;3. Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre (Austin Campus), Heidelberg, VIC, Australia;4. Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, VIC, Australia;5. Comprehensive Epilepsy Program, Alfred Health, Australia;1. National Institutes of Health, National Institute of Nursing Research, 1 Cloister Court, Bldg 60, Bethesda, MD 20892, USA;2. San Antonio Military Medical Center, Department of Sleep Medicine, 1100 Wilford Hall Loop, Bldg 4554, JBSA-Lackland, TX 78236, USA |
| Abstract: | IntroductionRecent research with neuropathologic or biomarker evidence of Alzheimer's disease (AD) casts doubt on traumatic brain injury (TBI) as a risk factor for AD. We leveraged the National Alzheimer's Coordinating Center to examine the association between self-reported TBI with loss of consciousness and AD neuropathologic changes, and with baseline and longitudinal clinical status.MethodsThe sample included 4761 autopsy participants (453 with remote TBI with loss of consciousness; 2822 with AD neuropathologic changes) from National Alzheimer's Coordinating Center.ResultsSelf-reported TBI did not predict AD neuropathologic changes (P > .10). Reported TBI was not associated with baseline or change in dementia severity or cognitive function in participants with or without autopsy-confirmed AD.DiscussionSelf-reported TBI with loss of consciousness may not be an independent risk factor for clinical or pathological AD. Research that evaluates number and severity of TBIs is needed to clarify the neuropathological links between TBI and dementia documented in other large clinical databases. |
| Keywords: | Alzheimer's disease Traumatic brain injury Cognitive decline Neurodegenerative disease NACC Concussion |
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