Neutrophil-related Variables Have Different Prognostic Effect Based on Primary Tumor Location in Patients With Metastatic Colorectal Cancer Receiving Chemotherapy |
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| Affiliation: | 1. Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan;2. Department of Biostatistics, The University of Tokyo, Tokyo, Japan;1. Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, People''s Republic of China;2. Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, People''s Republic of China;1. Department of Gastroenterology and Hepatology, St Antonius Hospital Nieuwegein, Nieuwegein, Netherlands;2. Department of Internal Medicine/Oncology, St Antonius Hospital Nieuwegein, Nieuwegein, Netherlands;3. Department of Internal Medicine/Oncology, Diakonessenhuis Utrecht, Utrecht, Netherlands;4. Department of Internal Medicine/Oncology, Meander Medical Center Amersfoort, Amersfoort, Netherlands;5. Department of Radiotherapy, University Medical Center Utrecht, Utrecht, Netherlands;6. Department of Surgery, St Antonius Hospital Nieuwegein, Nieuwegein, Netherlands;7. Department of Gastroenterology and Hepatology, Radboud University Medical Center Nijmegen, Nijmegen, Netherlands;1. Transitional Year Program, University of Puerto Rico-Medical Sciences Campus, San Juan, PR;2. Ad-Vance Medical Research, Ponce, PR;3. Department of Radiation Oncology, Auxilio Mutuo Hospital, San Juan, PR;4. Department of Cardiothoracic Surgery, Centro Cardiovascular de Puerto Rico y del Caribe, San Juan, PR;5. Ponce Hematology Oncology, Ponce, PR;1. Department of Internal Medicine, Mayo Clinic, Rochester, MN;2. Division of Medical Oncology, Mayo Clinic, Rochester, MN;3. Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, MN |
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| Abstract: | BackgroundClinical data reported a relationship between neutrophil-related variables and poor prognosis in patients with metastatic colorectal cancer (mCRC), but only platelet-to-lymphocyte ratio has been reported as prognostic.Patients and MethodsA retrospective analysis of 145 patients with mCRC, who received chemotherapy at the department of Oncology of the Ospedale Civile di Sanremo in 2010 to 2013, was performed, and a Cox model was built.ResultsIn the model, some variables were independently related with overall survival (OS) (resection of the primary tumor, number of drugs included in the first-line chemotherapy regimen), whereas neutrophil-related ones were not. However, after stratification by tumor location, neutrophil-related variables appeared associated with a poor survival among patients with a left-sided mCRC, and in particular, among those ones with a rectal tumor (hazard ratio, 3.732; 95% confidence interval, 1.575-8.845).ConclusionNeutrophil-related variables predicted outcome in patients with left-sided mCRC only. A high prevalence of consensus molecular subtype 4 CRC in patients with metastatic cancer of the rectum is suggested. |
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| Keywords: | Chemotherapy Colorectal cancer Neutrophil Prognosis Systemic inflammation |
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