| 甲腈咪胍实验治疗小鼠P615移植瘤及其抗肿瘤机理 |
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| 引用本文： | 张凤民,李呼伦,郭彩玲,李绍贤. 甲腈咪胍实验治疗小鼠P615移植瘤及其抗肿瘤机理[J]. 哈尔滨医科大学学报, 1990, 0(6) |
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| 作者姓名： | 张凤民 李呼伦 郭彩玲 李绍贤 |
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| 作者单位： | 哈尔滨医科大学微生物学教研室(张凤民，李呼伦，郭彩玲)，哈尔滨医科大学微生物学教研室(李绍贤) |
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| 摘 要： | 本文采用甲腈咪胍口服给药法,实验治疗小鼠P615移植瘤;并且利用单克隆抗体SPA菌体直接花环形成实验,测定小鼠脾T淋巴细胞亚群的变化。结果表明,甲腈咪胍具有抑制小鼠P615移植瘤细胞生长,延长荷瘤小鼠生存时间的作用;还可以降低荷瘤小鼠脾T淋巴细胞Lyt2(TS细胞)亚群的数目,调整L_3T_4/Lyt2比值恢复正常,发挥抗肿瘤效应。
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| 关 键 词： | 甲腈咪胍 T淋巴细胞 免疫抑制 肿瘤细胞移植 治疗学 |
Experimental Treatment of P615 Mice with Transplanted Tumor by Cimetidine and Its Antineoplastic Mechanism |
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| Zhang Fengmin et al. Experimental Treatment of P615 Mice with Transplanted Tumor by Cimetidine and Its Antineoplastic Mechanism[J]. Journal of Harbin Medical University, 1990, 0(6) |
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| Authors: | Zhang Fengmin et al |
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| Affiliation: | Department of Microbiology |
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| Abstract: | It is well known that the activation of Ts can be inhibited by cimetidine and that the function of immune system will be augmented therefore. In this report, P615 mice with transplanted tumor were experimentally treated with cimetidine administered orally, the change of splenic T subsets was detected by direct SPA rosette test. The results showed that the growth of P615 tumor can be inhibited, the number of splenic Lyt2. (Ts) was reduced and the ratio of L_3T_4/Lyt2 was normal again. It suggests that antitumorigenic ability of the mice has been augmented. |
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| Keywords: | Cimetidine T-Lymphocytes Immunosuppression Neoplasm seeding Therapeutics |
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