| 那格列奈对新诊断2型糖尿病患者炎性反应状态的影响 |
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| 引用本文： | 顾建芬,陈立波,吕术昕.那格列奈对新诊断2型糖尿病患者炎性反应状态的影响[J].疑难病杂志,2010,9(9):665-666. |
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| 作者姓名： | 顾建芬 陈立波 吕术昕 |
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| 作者单位： | 南山医院,内分泌科,深圳市第六人民医院,518052 |
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| 摘 要： | 目的探讨那格列奈对新诊断2型糖尿病患者炎性反应状态的影响。方法 40例新诊断2型糖尿病患者分为那格列奈组（观察组,20例）和生活方式调整组（对照组,20例）,检测治疗前及治疗12周后的血脂、糖化血红蛋白（HbA（1c））、白介素-2（IL-2）及C反应蛋白（CRP）的变化。结果治疗后2组各项指标均显著改善（P〈0.05）,而除HbA（1c）外观察组患者的血脂、IL-2和CRP均明显低于对照组（P〈0.05）。结论那格列奈可以改善新诊断2型糖尿病患者的炎性反应状态,可能与糖脂毒性的改善有关。
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| 关 键 词： | 糖尿病 2型 那格列奈 炎性反应 |
Nateglinide ameliorates low-grade inflammation in newly diagnosed type 2 diabetes |
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| GU Jian-fen,CHEN Li-bo,LV Shu-xin.Nateglinide ameliorates low-grade inflammation in newly diagnosed type 2 diabetes[J].Journal of Difficult and Complicated Cases,2010,9(9):665-666. |
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| Authors: | GU Jian-fen CHEN Li-bo LV Shu-xin |
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| Institution: | .Department of Endocrinology,the Shenzhen Sixth Hospital(Nanshan Hospital),Guangdong Province, Shenzhen 518052,China |
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| Abstract: | Objective To investigate the influence of nateglinide on low-grade inflammation in newly diagnosed type 2 diabetes.Methods 40 newly diagnosed type 2 diabetes were divided into 2 groups,20 cases of life style changed combined nateglinide therapy and 20 cases of life style changed.Plasma lipid profile,HbA_（1c）,IL-2,and CRP were measured before and after 12 weeks therapy.Results Plasma lipid profile,HbA_（1c）,IL-2,and CRP were signi ficantly improved in both groups（P0.05）,except HbA_（1c）,other indexs were lower in patients with life style changed combined nateglinide therapy than patients only with life style changed（P0.05）.Conclusion Nategli nide ameliorates low-grade inflammation in newly diagnosed type 2 diabetes,potential reason may caused by amelioration of hyperglycemia and lipidemia. |
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| Keywords: | Diabetes type 2 Nateglinide Inflammation reaction |
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