白介素18／白介素10比值与冠心病患者PCI后冠脉事件的关系

【目的】探索白介素18（IL-18）、白介素10（IL-10）与经皮冠脉内介入治疗（PCI）后冠脉事件（CE）发生的相关性，为预防PCI后CE的发生提供新思路。【方法】本研究纳入105例行PCI术的冠心病（CHD）患者，男性74例，女性31例，平均年龄（64．80±9．62）岁，根据随访结果把患者分为CE组和非CE组，采用酶联免疫吸附法分别测定两组患者血浆IL-18、IL-10，采用独立样本t检验分析两独立样本的均数差异，Logistic回归强迫引入法分析多个自变量与一个变量之间的线性数量关系。【结果】CE组患者PCI前血浆IL-18与IL-18／IL-10比值显著高于非CE组（P均〈0．01），CE组患者PCI前血浆IL-10显著低于非CE组（P〈0．01）。CHD患者血浆IL-18／IL-10比值、糖尿病、高血压、高脂血症分别使CHD患者PCI后CE的优势比（OR）值增加4．28倍、8．23倍、7．82倍、8．85倍（P均〈0．05）。【结论】除传统的CHD危险因素糖尿病、高血压、高脂血症外，CHD患者血浆IL-18／IL-10比值增大也增加CHD患者PCI后CE发生的风险。

Relationship Between Interleukin-18/interleukin-10 Ratio and Coronary Events in Coronary Heart Disease Patients after PCI

[Objective]To investigate the relationship between interleukin-18 （IL-18）, interleukin-10（IL- 10） and coronary events（CE） in coronary heart disease patients（CHD） after percutaneous coronary interven tion（PCI）, and provide new ideas for prevention of CE after PCI. [Methods] A total of 105 CHD patients who had been treated by PCI, including 74 men and 31 women, were enrolled in this study. Their average age was （64.80 ± 9.62） years old. The patients were divided into CE group and non-CE group according to the results of the follow up. The plasma IL-18 and IL-10 levels in the patients were measured by enzyme linked immunosorbent assay, t-test was used to analyze the age distinction between two independent samples. Logistic regression was employed to analyze the linear relationship between multiple variables and one variable. [Results] Plasma IL-18 and IL-18/IL-10 ratio in the CE group were higher than those in non-CE group（ P 〈0. 01）. Plasma IL- 10 in the CE group was lower than that in non-CE group （ P 〈0.01）. Logistic regression analysis showed that IL-18/IL-10 ratio, diabetes, byperlipidemia and hypertension increased the relative risk of CE in CHD patients＇after PCI by 4.28, 8.23, 7.82 and 8.85 times, respectively（ P 〈0.05）. [Conclusion]Except for traditional CHD risk factors such as diabetes and hyperlipidemia, IL-18/IL-10 ratio can also increase the risk of CE in CHD patients after PCI.