| 微透析取样和微柱液相色谱电化学检测法测定大鼠脑纹状体中的5-羟色胺 |
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| 引用本文： | 谢福明,黄铁华,彼得·基辛格.微透析取样和微柱液相色谱电化学检测法测定大鼠脑纹状体中的5-羟色胺[J].中国药理学报(英文版),1995(5). |
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| 作者姓名： | 谢福明 黄铁华 彼得·基辛格 |
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| 作者单位： | Bioanalytical Systems，Inc，2701 Kent Avenue，West Lafayette IN 47906 USA，Bioanalytical Systems，Inc，2701 Kent Avenue，West Lafayette IN 47906 USA，Bioanalytical Systems，Inc，2701 Kent Avenue，West Lafayette IN 47906 USA |
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| 摘 要： | 目的:建立一个测定生物样本中5-羟色胺的灵敏方法.方法:将微透析取样和微柱液相色谱电化学检测(LCEC)有机结合,建立灵敏的分析方法.结果:很容易地测定了自由活动大鼠脑纹状体透析液中fg-pg的5-羟色胺变化.结论:本法对生物活体研究很有用.健康大鼠脑纹状体内5-羟色胺水平是相当稳定的.
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| 关 键 词： | 5-羟色胺 微透析 液相色谱 电化学 纹状体 |
Microdialysis sampling and microbore liquid chromatography with electrochemical detection for determination of serotonin in rat brain striatum |
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| XIE Fu-Ming,HUANG Tie-Hua,Peter T KISSINGER.Microdialysis sampling and microbore liquid chromatography with electrochemical detection for determination of serotonin in rat brain striatum[J].Acta Pharmacologica Sinica,1995(5). |
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| Authors: | XIE Fu-Ming HUANG Tie-Hua Peter T KISSINGER |
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| Abstract: | AIM:To develop a sensitive method for determination of serotonin in biological samples. METHODS:A combination of microdialysis sampling and microbore liquid chromatogra-phy with electrochemical detection (LCEC) was established. RESULTS:Changes of serotonin in fg or pg in microdialysates from brain striatum of the free moving rat were easily determined. CONCLUSION:This developed method was useful for living animal research. Serotonin level in corpus striatum healthy rats was quite stable. |
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| Keywords: | serotonin microdialysis liquid chromatography electrochemistry corpus striatum |
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