The effects of normovolemic hemodilution with dextran-40 on acute myocardial ischemia/ reperfusion injury in rabbits |
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Authors: | Ruan Han-dan Dong Chuan-ren Ling Hong |
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Institution: | (1) Department of Pathophysiology, Hubei Medical College, Wuhan |
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Abstract: | Summary The effects of decreasing blood viscosity by normovolemic hemodilution with dextran-40 or normal saline (NS) on myocardial
lipid peroxides, Superoxide dismutase, infarct size and left ventricular function during acute myocardial ischemia/reperfusion
were studied in rabbit’s. It was found that normovolemic hemodilution with dextran-40 could decrease the content of ischemic
myocardial malondialdehyde and preserve ischemic myocardial superoxide dismutase activity after 1 h of coronary occlusion
followed by 1 h of reperfusion. However, after administration of NS only a tendency in this aspect exhibited without statistical
significance. Besides, hemodilution with dextran-40 reduced infarct size and improved left ventricular systolic function after
1 h of ischemia followed by 23 h of reperfusion. These results suggest that normovolemic hemodilution with dextran-40 may
have anti-injury effect on acute myocardial ischemia/reperfusion to a certain degree. |
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Keywords: | acute myocardial ischemia/reperfusion injury dextran/low molecular hemodilution lipid peroxides Superoxide dismutase |
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