| 星点设计-效应面优化法优化注射用Cheliensisin A冻干乳剂 |
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| 引用本文： | 赵栋,龚涛,梁湖沂,陈琳琳,张志荣.星点设计-效应面优化法优化注射用Cheliensisin A冻干乳剂[J].华西药学杂志,2007,22(3):275-279. |
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| 作者姓名： | 赵栋 龚涛 梁湖沂 陈琳琳 张志荣 |
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| 作者单位： | 四川大学华西药学院,四川,成都,610041;四川大学生命科学院,四川,成都,610064 |
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| 摘 要： | 目的 优化注射用Cheliensisin A冻干乳剂的处方.方法 以高压乳匀法制备乳剂,加适当冻干保护剂冻干,以冻干制剂的外观、加水复溶情况、粒径及多相分散系数(PDI)为指标,采用星点设计-效应面优化法确定较优处方.结果 大豆磷脂、中链脂肪酸酯和Cheliensisin A的浓度分别为4%、15%和0.2%时,制得的Cheliensisin A冻干乳剂外观结实、光滑平整;加水再分散性好;粒径为168±5 nm;PDI为0.133±0.070;适合静脉给药.结论 应用星点设计-效应面优化法能够快速方便地筛选出Cheliensisin A冻干乳剂的较优处方.
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| 关 键 词： | Cheliensisin A 冻干乳剂 星点设计-效应面优化法 |
| 文章编号： | 1006-0103（2007）03-0275-05 |
| 修稿时间： | 2006-11 |
Optimization of Freezing-dried Cheliensisin A submicron emulsion for intravenous injection by Central composite design-response surface methodology |
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| ZHAO Dong,GONG Tao,LIANG Hu-yi,CHEN Lin-lin,ZHANG Zhi-rong.Optimization of Freezing-dried Cheliensisin A submicron emulsion for intravenous injection by Central composite design-response surface methodology[J].West China Journal of Pharmaceutical Sciences,2007,22(3):275-279. |
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| Authors: | ZHAO Dong GONG Tao LIANG Hu-yi CHEN Lin-lin ZHANG Zhi-rong |
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| Institution: | 1. West China School of Pharmacy, Sichuan University, Chengdu, 610041, China; 2. School of Life Sciences, Sichuan University, Chengdu 610041, China |
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| Abstract: | |
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| Keywords: | Cheliensisin A Freezing- dried submicron emulsion Central composite design- response surface methodology |
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