| 口服葛根素固体脂质纳米粒的制备 |
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| 引用本文： | 李晨睿,蒋学华,袁牧,任静,谈斐. 口服葛根素固体脂质纳米粒的制备[J]. 华西药学杂志, 2007, 22(4): 378-380 |
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| 作者姓名： | 李晨睿 蒋学华 袁牧 任静 谈斐 |
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| 作者单位： | 四川大学华西药学院,四川,成都,610041;广州医学院,广东,广州,510128 |
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| 摘 要： | 目的 研究葛根素固体脂质纳米粒(Pue-SLN)的制备工艺,并考察其制备过程中的影响因素.方法 采用溶剂扩散法制备Pue-SLN,并考察其形态、粒径分布、包封率、载药量、Zeta电位等.结果 Pue-SLN在透射电镜下呈球形或近球形,分布均匀,平均粒径为160 nm,包封率达80%～85%,平均Zeta电位为-35.43 mV.结论 所用制备工艺简单稳定,可用于制备口服Pue-SLN.
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| 关 键 词： | 固体脂质纳米粒 葛根素 包封率 制备 |
| 文章编号： | 1006-0103（2007）04-0378-03 |
| 修稿时间： | 2006-10-01 |
Preparation of puerarin solid lipid nanoparticles for oral administration |
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| LI Chen-rui,JIANG Xue-hua,YUAN Mu,REN Jing,TAN Fei. Preparation of puerarin solid lipid nanoparticles for oral administration[J]. West China Journal of Pharmaceutical Sciences, 2007, 22(4): 378-380 |
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| Authors: | LI Chen-rui JIANG Xue-hua YUAN Mu REN Jing TAN Fei |
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| Affiliation: | 1. West China School of Pharmacy, Sichuan University, Chengdu 610041 ,China;2. Guangzhou Medical School, Guangzhou 510182,China |
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| Abstract: | OBJECTIVE To study the production techniques of Puerarin Solid Lipid Nanoparticle(Pue-SLN) and to explore the influence factors in the process.METHODS The solvent injection approach was employed to prepare Pue-SLN.The characteristics were studied in terms of the morphology,particle size distribution,drug loading,entrapment efficiency and Zeta-potential.RESULTS The Pue-SLN in transmission electron microscopy(TEM) mostly had spherical shape. The average size was about 160 nm with EY ranging in 80%-85% and zeta-potential of-35.43 mV.CONCLUSION The production technique is simple and stable which could be used to prepare Pue-SLN. |
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| Keywords: | Solid lipid nanoparticle Puerarin Entrapment efficiency Preparation |
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