| 糖尿病患者角膜上皮损伤愈合延迟的研究进展 |
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| 引用本文： | 吴燕妮,张琪. 糖尿病患者角膜上皮损伤愈合延迟的研究进展[J]. 国际眼科杂志, 2020, 20(8): 1367-1370 |
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| 作者姓名： | 吴燕妮 张琪 |
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| 作者单位： | 400016 中国重庆市,重庆医科大学附属第一医院眼科;400016 中国重庆市,重庆医科大学附属第一医院眼科 |
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| 基金项目： | 重庆市科卫联合医学科研项目(No.2019MSXM003); 重庆市自然科学基金面上项目(基础研究与前沿探索)(No.cstc2019jcyj-msxmX0398) |
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| 摘 要： | 糖尿病患者角膜上皮损伤后愈合延迟较常见，持续不愈合的角膜损伤可导致复发性上皮糜烂、角膜溃疡甚至角膜穿孔，影响视功能。本文就糖尿病患者角膜上皮损伤愈合延迟的病理基础、发病机制以及相关治疗的研究进展做一综述。概述了糖尿病患者角膜上皮结构和功能的改变，阐述了高糖、蛋白酶、泪膜、生长因子和细胞因子、角膜神经以及microRNA等在发病机制中的作用，总结了治疗糖尿病患者角膜上皮损伤愈合延迟的最新思路。
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| 关 键 词： | 糖尿病 角膜上皮 愈合延迟 |
| 收稿时间： | 2019-12-04 |
| 修稿时间： | 2020-06-28 |
Recent advances in research on delayed corneal epithelial wound healing in diabetes |
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| Yan-Ni Wu and Qi Zhang. Recent advances in research on delayed corneal epithelial wound healing in diabetes[J]. International Eye Science, 2020, 20(8): 1367-1370 |
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| Authors: | Yan-Ni Wu and Qi Zhang |
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| Affiliation: | Department of Ophthalmology,the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China and Department of Ophthalmology,the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China |
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| Abstract: | Delayed healing of diabetic corneal epithelial wound is a commonly encountered condition, and persistent corneal epithelial defects may give rise to recurrent epithelium erosion, corneal ulceration, and subsequent perforation as well as affecting visual loss. The current review focused on the pathological basis, updates of the pathogenesis, and recent advances in the treatment of delayed healing of diabetic corneal epithelial wounds, wherein the roles of hyperglycemia, tear film, proteases, cytokines, corneal nerves and genes were elaborated, and the latest views on treatment strategies, for the delayed healing were summarized as well. Recent advances in research on delayed corneal epithelial wound healing in diabetes mellitus. |
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| Keywords: | diabetes mellitus corneal epithelium delayed wound healing |
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