ER、PR、Her-2在乳腺癌中的表达 |
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引用本文: | 施烯,林小燕,黄沂,张志锋,王日雄,曾乌查. ER、PR、Her-2在乳腺癌中的表达[J]. 肿瘤研究与临床, 2006, 21(1): 461-462,465. DOI: 10.3760/cma.j.issn.1006-9801.2009.07.010 |
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作者姓名: | 施烯 林小燕 黄沂 张志锋 王日雄 曾乌查 |
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作者单位: | 福建医科大学附属第一医院化疗科,福州,350005; |
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摘 要: | 目的 探讨乳腺癌组织中雌激素受体(ER)、孕激素受体(PR)、人类表皮生长因子受体-2(Her-2)的表达与临床特征的关系.方法 用免疫组织化学法检测311例乳腺癌组织中ER、PR、Her-2的表达.结果 311例乳腺癌组织中Her-2阳性表达明显低于ER和PR,分别为87例(27.97%)、185例(59.49%)和195例(62.70%).与非浸润性乳腺癌相比,ER、PR在浸润性乳腺癌中的表达明显减少(P<0.05).ER的表达随乳腺癌TNM分期增加而减少(P<0.05),而PR和Her-2的表达与TNM分期无关(P0.05).与无腋窝淋巴结转移者相比,有腋窝淋巴结转移的乳腺癌组织中ER表达明显减少,Her-2表达明显增加(P<0.05).结论 ER、PR、Her-2与乳腺癌的临床特征密切相关,其可能参与乳腺痛的生物学行为调控,常规检测ER、PR、Her-2的表达可为乳腺癌治疗提供依据.
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关 键 词: | 乳腺肿瘤 雌激素受体 孕激素受体 受体,表皮生长因子 |
Expressions of ER, PR and Her-2 in breast cancer |
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Abstract: | Objective To investigate the relationship between expressions of estrogen receptor (ER), progesterone receptor(PR) and human epidermal growth factor receptor 2 (Her-2) in 311 cases of breast cancer tissue and their clinical feature. Methods The expressions of ER, PR and Her-2 were detected by immunohistochemistry in 311 cases of breast cancer tissue proved pathologically. Results The positive rate of ER, PR and Her-2 were 59.49 %, 62.70 % and 27.97 % respectively in breast cancer tissues. Compared with non-invasive breast cancer, the expressions of ER and PR significant decreased in invasive breast cancer (P<0.05). The expression of ER decreased to follow the elevation of TNM status of breast cancer (P<0.05). Compared with patients who had not metastasis in axiUary lymph node, the expressions of ER significantly decreased and the expressions of Her-2 significantly increased in patients who had metastasis in axillary lymph node (P<0.05). Conclusion These findings indicate that ER, PR and Her-2 are intimate correlation with clinical feature and maybe participate in biological behaviour regulation of breast cancer. The routine detecting of ER, PR and Her-2 may provide the evidence for breast cancer treatment. |
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Keywords: | Breast neoplasmsERPRReceptor Her-2 |
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