化疗对肠屏障功能的影响及其防治

化疗是对恶性肿瘤患者常用的治疗方法，但化疗药物特别是大剂量时对化疗敏感组织可造成严重损伤。化疗对肠黏膜的损伤导致肠道屏障功能障碍，这在全身感染、感染性休克及感染综合征发病中起着很重要作用。作者对化疗所导致的肠黏膜屏障功能损伤及其预防和治疗进展作一综述。

Prevention and treatment of chemotherapy-induced intestinal barrier dysfunction

Chemotherapy has been shown to be effective in the treatment of patients malignancies,however, anticancer drugs, particularly high-dose, also damage other chemosensitive tissues such as the intestinal mucosa, and these adverse effects can impair intestinal mucosal barrier. The derangement in the barrier function plays a central role in the pathophysiology of systemic infection, shock, and sepsis syndrome. The chemotherapy-induced intestinal barrier dysfunction and its prevention and treatment had been reviewed.