| 夏枯草醇提物对实验性糖尿病肾脏病变的作用 |
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| 引用本文： | 冯玛莉,贾力莉,武玉鹏,裴小静.夏枯草醇提物对实验性糖尿病肾脏病变的作用[J].山西中医学院学报,2000,1(2):7-9. |
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| 作者姓名： | 冯玛莉 贾力莉 武玉鹏 裴小静 |
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| 作者单位： | 山西省中医药研究院!山西太原030012 |
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| 摘 要： | 目的 :观察夏枯草醇提物对实验性糖尿病大鼠肾脏病变的防治作用。方法 :夏枯草经乙醇、氯仿提取得醇提物 (AEP)。腹腔注射链脲佐菌素后 4周 ,造成大鼠糖尿病模型 (DM ) ,灌胃AEP 10 0mg/kg、2 0 0mg/kg 4周 ,测定血糖、肾功能和肾组织醛糖还原酶活性。结果 :AEP能显著降低糖尿病大鼠尿蛋白 ,AEP 10 0mg/kg能降低血清尿素氮、肌酐含量 ;能显著降低DM大鼠肾组织醛糖还原酶 (AR)活性。结论 :AEP对糖尿病大鼠并发肾脏病变有一定的防治作用 ,其作用机制可能通过抑制醛糖还原酶活性以减轻山梨醇蓄积造成相关组织器官的损害。
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| 关 键 词： | 夏枯草醇提物 糖尿病 肾脏病变 醛糖还原酶 |
Effect of the alcohol extract of spica prunellae on experimental diabetic nephropathy |
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| Feng Mali et al..Effect of the alcohol extract of spica prunellae on experimental diabetic nephropathy[J].Journal of Shanxi College of Traditional Chinese Medicine,2000,1(2):7-9. |
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| Authors: | Feng Mali |
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| Abstract: | Objective: We examined the prevention and cure effect of the Alcohol extract of spica prunellae (AEP) on experimental diabetic nephropathy in rat. Methods: The AEP was obtained by extracting spica prunellae with ethanol and chloroform. After 4 weeks experimental diabetic model was induced by i.p. rats streptozotocin(STZ), DM rats were administratred the AEP 100mg·kg -1 ,200mg·kg -1 for 4 weeks, blood glucose, kidney function and activity of kidney aldose reductase were determined. Results: The AEP decreased significantly urinary protien in diabetic rats. The AEP 100mg·kg -1 decreased blood urea nitrogen(BUN) and creatinine(Cr) in diabetic rats. The AEP deceased significantly activity of kidney aldose reductase in diabetic rats. Conclusions: The AEP had certain degree of preventing diabetic nephropathy. The results suggested that the AEP defect diabetic nephropathy by inhibiting activity of aldose reductase to decrease associated tissue or organ injuries caused by accumulation of sorbitol. |
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| Keywords: | alcohol extract of spica prunellae(AEP) diabetic nephropathy aldose reductase |
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