| 白藜芦醇氧烷酸类衍生物的设计与合成 |
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| 引用本文： | 王强,陈波. 白藜芦醇氧烷酸类衍生物的设计与合成[J]. 中国中医药现代远程教育, 2014, 0(22): 160-161 |
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| 作者姓名： | 王强 陈波 |
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| 作者单位： | 江西省金溪县人民医院药剂科;安徽中医药大学药学院 |
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| 摘 要： | 目的：寻找更好的苯氧烷酸类降血脂药物。方法以白藜芦醇、α-溴代异丁酸乙酯为原料，经SN1型取代反应得到二种苯氧烷酸类化合物。所有目标化合物通过红外光谱（IR）、核磁共振氢谱（1H-NMR）、质谱（MS）进行结构确证。结果设计、合成并得到相应的产物。结论为降血脂药物开发提供线索。
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| 关 键 词： | 白藜芦醇氧烷酸衍生物 设计 合成 |
The Design and Synthesis of Resveratrol Oxyalkanoic Acids Derivatives |
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| Wang Qiang;Chen Bo. The Design and Synthesis of Resveratrol Oxyalkanoic Acids Derivatives[J]. Chinese Medicine Modern Distance Education of China, 2014, 0(22): 160-161 |
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| Authors: | Wang Qiang Chen Bo |
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| Affiliation: | Wang Qiang;Chen Bo;Huang Peng;The Jinxi County People’s hospital of Jiangxi Province;Pharmacy college, Anhui University of Chinese Medicine; |
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| Abstract: | Objective The purpose is to search for potent lipid-lowering agents with structures of phenoxyalkanoic acids. Methods Se-lecting resveratrol as leading compound, we designed and synthesized two phenoxyalkanoic acids compounds which through the SN1 reac-tion. The structure of compounds a and b were characterized by using IR, 1H-NMR and MS. Results The target compounds were pre-pared. Conclusion The experimental results were provide clues for the development of cholesterol-lowing drugs. |
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| Keywords: | resveratrol oxyalkanoic acids derivatives design synthesis |
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