| 人组织工程全层活性皮肤在深度烧伤创面的临床应用 |
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| 引用本文： | 刘亚玲,金岩,聂鑫,胡大海.人组织工程全层活性皮肤在深度烧伤创面的临床应用[J].第四军医大学学报,2004,25(3):224-228. |
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| 作者姓名： | 刘亚玲 金岩 聂鑫 胡大海 |
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| 作者单位： | 第四军医大学,西京医院整形外科中心烧伤外科,陕西,西安,710033;第四军医大学,口腔医学院组织病理学教研室,陕西,西安,710033 |
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| 基金项目： | 8 63计划重大专项 [组织器官工程 (2 0 0 2AA2 0 50 4 1 ) ] |
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| 摘 要： | 目的 :观察人组织工程全层活性皮肤 (ActivSkin)在深度烧伤创面的临床应用效果 .方法 :采用ActivSkin修复深度创面 31例 ,观察创面愈合情况 ;观察应用ActivSkin后受体、供体的性别对创面愈合的影响 .并对病例进行随访 .结果 :治疗组深II度创面 2 5例 ,愈合时间比对照组提前 6d(P <0 .0 5 ) .III度创面 6例 ,愈合时间比对照组提前 2 0d(P <0 .0 5 ) .随访病例提示 :ActivSkin移植后组织相容性好 ,作为角质细胞和成纤维细胞三维结构支架的牛胶原膜在体内可降解 ,无免疫排异及局部炎症反应发生 .结论 :ActivSkin是一种具有生物活性、较理想的修复深度烧伤创面的新型皮肤代用品 .
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| 关 键 词： | 皮肤 组织工程 烧伤 临床应用 |
| 文章编号： | 1000-2790(2004)03-0224-05 |
| 修稿时间： | 2003年12月21 |
Clinical application of human tissue-engineered active skin with full thickness on deep burn wounds |
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| LIU Ya Ling ,JIN Yan ,NIE Xin ,HU Da Hai.Clinical application of human tissue-engineered active skin with full thickness on deep burn wounds[J].Journal of the Fourth Military Medical University,2004,25(3):224-228. |
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| Authors: | LIU Ya Ling JIN Yan NIE Xin HU Da Hai |
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| Institution: | LIU Ya Ling 1,JIN Yan 2,NIE Xin 2,HU Da Hai 1 1Department of Burn Surgery,Center of Plastic Surgery,Xijing Hospital,2Department of Oral Histology and Pathology,Stomatological College,Fourth Military Medical University,Xi'an 710033,China |
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| Abstract: | AIM: To observe the clinical effect of human tissue engineered active skin (ActivSkin) with full thickness on deep burn wounds. METHODS: Thirty one cases of deep burn wounds were repaired with human tissue engineered active skin. The time to complete closure and the ratios of complete healing for ActivSkin treated wounds were observed. The effect of sexual identity of ActivSkin recipients (patients) and donors on complete healing was observed. All the patients were followed up. RESULTS: Compared to control group, the time to complete closure in ActivSkin therapy group was shortened by 6 d for 25 deep second degree burn wounds ( P <0.05), and by 20 d for 6 full thickness burn wounds ( P < 0.05) . The ratios of complete healing in ActivSkin therapy group and control group were both 100%. The sexual identity of recipients (patients) and skin donors had no influence on the time of complete closure of wounds ( P >0.05). The follow up results showed that ActivSkin might be admited by recipients and degraded after application. We did not detect the immunological rejection and inflammatory reaction in recipient area after ActivSkin treatment. CONCLUSION: ActivSkin is a new bioactive skin substitute for the repairing of deep burn wounds. |
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| Keywords: | skin tissue engineered burns clinical application |
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