磷酸肌酸钠治疗早产儿缺氧缺血性心肌损伤疗效观察

目的：观察磷酸肌酸钠对早产儿缺氧缺血性心肌损伤的疗效。方法选择该院2009年7月至2011年11月收治的因窒息引起的心肌损伤早产儿104例，随机分为治疗组（56例）和对照组（48例），两组早产儿均给予常规治疗。治疗组在常规治疗的基础上给予磷酸肌酸钠0.5 g/d；对照组予维生素C 100 mg/kg，每天1次，1个疗程后（10 d）观察治疗前、后肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）、心肌肌钙蛋白I（cTnI）的变化。结果治疗组早产儿治疗后CK、CK-MB和cTnI水平较对照组明显降低，差异均有统计学意义（P＜0.05）。结论磷酸肌酸钠治疗早产儿缺氧缺血性心肌损伤有效。

Clinical observation of creatine phosphate sodium on premature infants with hypoxic ischemic myocardial injury

Objective To observe the effect of creatine phosphate sodium on premature infants with hypoxic ischemic myocardial injury. Methods A total of 104 premature infants with hypoxic ischemic myocardial injury,who were in the hospital from June 2009 to November 2011,were randomized into treatment group（n=56）and control group（n=48）. Based on the conven-tional therapy,the treatment group was added with creatine phosphate sodium,0.5 g daily;the control group was added with vita min C 100 mg/kg,once daily. After a course of treatment（10 d）,the changes of creatine kinase（CK）,CK-MB and cardiac tro-poninI（cTnI） in both groups were observed. Results After treatment,the levels of CK,CK-MB and cTnI of the premature infants in the treatment group reduced more obviously than those in the control group ,and the difference was statistically significant （P〈0.05）. Conclusion Creatine phosphate sodium is effective for the treatment of premature infants with hypoxic ischemic myocar-dial damage.