Effect of magnesium lithosperamate B on D-galactosamine induced liver injury in rats |
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| Authors: | Ping Lin Mizoguzhi Yasuhiro Morisawa Seiji |
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| Affiliation: | 1. Liver Diseases Research Center, Shanghai Academy of Traditional Chinese Medicine, 200032, Shanghai
2. Division of biochemistry, Department of Medicine, Osaka City University, Japan
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| Abstract: | Treated the experimental acute liver injury rat induced by D-galactosamine with magnesium lithosperamate-B could significantly lower the serum activity of alanine transaminase and aspartate aminotransferase, relieve the necrosis of hepatocytes and elevate the levels of products of arachidonic acid (6-ke-to-prostaglandin 1α, prostaglandin D2 and the total prostaglandin) in liver. These results suggested that magnesium lithosperamate B was one of the main components ofSalvia miltiorrzae in treating liver injury, the action on elevating the total prostaglandin in liver might be its mechanism. |
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