Bidirectional regulatory effect of listen injection on sex hormones in senile female patients with coronary heart disease of kidney Deficiency typeon sex hormones in senile female patients with coronary heart disease of kidney Deficiency type

Objective: To assess the efficacy of Lishen injection (LSI) in treating coronary heart disease (CHD).Methods: The effect of LSI on serum estradiol (E₂) testosterone (T) and E₂/T ratio in 30 postmenopausal patients with CHD of Kidney Deficiency (KD) were observed.Results: (l) Serum E₂ and the E₂/T ratio were lower (P < 0.01) in the group of Kidney Yang Deficiency type (KYaDT) and higher (P < 0.01) in the group of Kidney Yin Deficiency type (KYiDT) as compared with normal control. (2) After treatment with LSI the levels of serum E₂ and the E₂/T ratio were elevated in the KYaDT group (P < 0.01) and lowered in the KYiDT group (P < 0.01). Both approached the normal level (P >0.05). (3) The levels of T in both groups were unaffected (P >0.05) before and after treatment.Conclusion: The imbalance of Kidney-Yin and Kidney-Yang is correlated to the disturbance of sex hormones and LSI could not only regulate the Kidney-Yin and Kidney-Yang, improve the symptoms of KD, but also reverse the disturbance of sex hormone. With a good bidirectional regulatory effect on E₂, it is beneficial on balance of sex hormones of both sexes in the inner environment of human body.