维生素E对心肌损伤的保护作用

用克山病病区粮和非病区粮喂养大鼠,并以锰和异丙基肾上腺素(ISO)作为条件因素建立动物心肌损伤模型,观察维生素E对心肌损伤的保护作用。实验结果表明,补充维生素E组(C和D组)大鼠心肌和肝脏脂质过氧化物(MDA)含量明显下降,心肌的细胞色素氧化酶和琥珀酸脱氢酶活性有不同程度的提高。心肌坏死检出率和坏死面积也有降低和缩小的趋势。而非病区粮+Mn+VE+ISO组心肌坏死检出率最低,坏死面积最小,可能与非病区粮中含硒量高有关。

A Study on Effects of Vitamin E on Cardiac Lesion

The rats were fed on grains Produced in the endemic region of Keshan disease and grains Produced in no nendemic region, and besides, manganese (Mn) and isoproterenol (ISO) were added respectivels. Experimental animals were divided into four groups: A group non-endemic grains+Mn+ISO; B group endemic grains+Mn+ISO; C group non-endemic grains+Mn+VE+ISO; D group endemic grains+Mn+VE+ISO. The results showed that the level of MDA in the heart, the liver and the serum were apparently lower in the groups C and D(VE supplementation), compared with those in the groups A and B. Activity of cytochemical reaction in cytochrome and succin odehydrogenase of cardiac mitochondria in the groups C and D were increased. Detectable rate and extent of the cardiac necrosis also tended to reduction in the groups C and D. Detectable rate and extent of the cardiac necrosis remarkbly reduced in the group C (non-endemic grains). Those finding suggested that selenum may probably exert protective effects on cardiac lesion, in addition VE.