The human type II collagen gene (COL2A1) assigned to 12q14.3 |
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| Authors: | M. L. LAW &dagger ,L. TUNG,H. G. MORSE &dagger ,R. BERGER,C. JONES &dagger ,K.S.E. CHEAH| § ,E. SOLOMON§ |
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| Affiliation: | *Eleanor Roosevelt Institute for Cancer Research;†Department of Pediatrics, of the University of Colorado Health Sciences Center, 4200 East Ninth Avenue, B-129, Denver, CO 80262;†Department of Biochemistry, Biophysics and Genetics, of the University of Colorado Health Sciences Center, 4200 East Ninth Avenue, B-129, Denver, CO 80262;§Laboratory of Somatic Cell Genetics, Imperial Cancer Research Fund, P.O. Box 123, Lincoln's Inn Fields, London WC2A 3PX;|Department of Biochemistry, Hong Kong University, Hong Kong |
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| Abstract: | A cosmid clone containing the entire human type II α1 collagen gene ( COL2A1 ) was used as probe in the Southern analysis of DNA from a panel of human/hamster somatic cell hybrids containing different portions of human chromosome 12. Two of the hybrids exhibited a similar terminal deletion q14.3→qter, but one was positive for the gene while the other was negative. Therefore, the gene must reside in the region q14.3. |
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