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| 情绪应激后大鼠颞下颌组织学及关节盘内P物质的相关变化 | |
| 引用本文： | 吴高义,陈磊,司武俊,王昭领,朱国雄. 情绪应激后大鼠颞下颌组织学及关节盘内P物质的相关变化[J]. 中华老年口腔医学杂志, 2011, 9(1): 15-17,22 |
| 作者姓名： | 吴高义 陈磊 司武俊 王昭领 朱国雄 |
| 作者单位： | 1. 济南军区总医院口腔科,山东,250031 2. 济南市口腔医院正畸科,山东,250001 3. 北京口腔种植培训中心,北京,100032 |
| 基金项目： | 博士后基金(20100481522)济南军区总医院院长基金 |
| 摘 要： | 目的:观察情绪应激后大鼠颞下颌关节(1temporomandibular joint,TMJ)盘内P物质(substance P,SP)的表达及微结构的变化,探讨情绪因素对TMJ的影响.方法:SD大鼠90只,随机分为3组.包括情绪应激组,对照组及足部电击组,每组30只.人为造成情绪应激的动物模型,分别在1周,3周,5周时取对照组和情绪应激组大鼠的颞下颌关节,在同一部位的切片,行SP免疫组化染色.光镜观察,图像分析,并与对照组进行比较.结果:颞下颌关节盘内能发现有明显的SP阳性神经纤维分布,主要分布在关节盘前、后带,且多分布在近盘边缘部,图像分析表明单视野中SP阳性纤维数与对照组差异显著(P<0.01);对照组与情绪应激组1周之间有显著性差异(P<0.05),和3周、5周之间差异不显著(P>0.05).结论:在大鼠情绪应激状态下TMJ的一系列病理性改变中,P物质可能参与了这种病理过程,但各实验组间的变化差异有所不同. |
| 关 键 词： | P物质 颞下颌关节 情绪应激 |
The expression of SP in the temporomandibular joints of the rats undergone emotional stress |
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| WU Gao-yi,CHEN Lei,SI Wu-jun,WANG Zhao-ling,ZHU Guo-xiong. The expression of SP in the temporomandibular joints of the rats undergone emotional stress[J]. Chinese JOurnal of Geriatric Dentistry, 2011, 9(1): 15-17,22 | |
| Authors: | WU Gao-yi CHEN Lei SI Wu-jun WANG Zhao-ling ZHU Guo-xiong |
| Affiliation: | WU Gao-yi,CHEN Lei,SI Wu-jun,WANG Zhao-ling,ZHU Guo-xiong.(Department of Stomatology,Jinan General Military Hospital,Jinan,Shandong 250031,China) |
| Abstract: | Objective:To observe the SP expression in the temporomandibular joints(TMJ) of the rats undergone emotional stress and discuss the relationship between emotional stress and temporomandibular joint disorder(TMD).Methods:90 SD rats were averagely divided into 3 groups:experimental,electric foot-shock and control group.In the experimental group,the animal model of emotional stress was made.The TMJ pathology undergone emotional stress for 1,3 and 5 weeks was observed.The SP expression was examined with SABC imm... |
| Keywords: | SP temporomandibular joint emotional stress |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |