应用ADC值对新生儿缺氧缺血性脑病追踪复查的初步研究

目的 应用磁共振弥散张量成像定量测定ADC值,探讨ADC值在随访复查婴幼儿期缺氧缺血性脑病（HIE）中的应用价值,揭示HIE影响患儿脑髓鞘发育及预后状况的特征.方法 追踪复查45例6-30个月婴幼儿期足月HIE患儿,依据新生儿期初查时临床表现分为轻度、中度和重度三组进行DTI检查,测定三组患儿相同感兴趣区的表观弥散系数 （ADC）值.结果 ADC值在胼胝体压部、内囊后肢、放射冠、额叶白质、顶叶白质、豆状核各个感兴趣区的组间差异均有统计学意义;除豆状核外,ADC值随病情加重而升高.结论 磁共振弥散张量成像的ADC值,在HIE追踪复查中可定量反映新生儿期不同轻重程度HIE患儿脑损伤对不同时期脑白质髓鞘发育的影响度,较常规磁共振成像评价更为早期、准确、客观、敏感;为HIE患儿脑损伤程度提供了有价值的监测指标.对新生儿缺氧缺血性脑病的病情评估具有重要意义.

The Role of ADC Values in Evaluating Follow-Up Value of Neonatal Hypoxic-Ischemic Encephalopathy: Initial Experience

Objective To determine the utility of using quantitative diffusion isotropy value as an objective means of detection infants who suffered from hypoxic-ischemic encephalopathy(HIE) in full-term neonatal period.In order to evaluate the follow-up value of ADC value on full-term HIE.Methods Conventional MR images and quantitative diffusion tensor MR images from 45 infants who had clinically diagnosed HIE before,including 20 cases of mild type,16 cases of moderate type,9 cases of severe type.Apparent diffusion c...