| 替比夫定和恩替卡韦治疗HBeAg阳性慢性乙型肝炎患者早期疗效分析 |
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| 引用本文： | 徐鹤翔,余亚新,张明侠,吴亚平,刘兴祥,陈勇. 替比夫定和恩替卡韦治疗HBeAg阳性慢性乙型肝炎患者早期疗效分析[J]. 实用肝脏病杂志, 2011, 14(4): 265-267. DOI: 10.3969/j.issn.1672-5069.2011.04.009 |
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| 作者姓名： | 徐鹤翔 余亚新 张明侠 吴亚平 刘兴祥 陈勇 |
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| 作者单位： | 1. 徐州医学院附属医院感染性疾病科,江苏省徐州市,221002
2. 淮安市第四人民医院肝病研究所 |
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| 摘 要： | 目的比较替比夫定与恩替卡韦治疗HBeAg阳性慢性乙型肝炎患者24周疗效及安全性。方法将60例HBeAg阳性慢性乙型肝炎患者随机分为替比夫定组和恩替卡韦组,比较两组治疗第12周和24周的疗效。结果在治疗12周时,两组患者HBV DNA低于检测水平和ALT复常率相比较,差异无统计学意义（P〉0.05）,替比夫定治疗组HBeAg阴转率和HBeAg血清学转换率高于恩替卡韦组（36.7%对14.3%,26.7%对6.7%,P〈0.05）;在治疗24周时,两组HBV DNA低于检测水平、ALT复常率、HBeAg血清学转换率相比较,差异均无统计学意义（P〉0.05）,而替比夫定组HBeAg阴转率高于恩替卡韦组（P〈0.05）;多因素Logistic回归分析发现仅基线ALT水平高的患者更易出现HBeAg血清学转换。结论替比夫定和恩替卡韦治疗CHB患者疗效相当,但替比夫定治疗患者HBeAg阴转率稍高于恩替卡韦治疗。
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| 关 键 词： | 慢性乙型肝炎 HBeAg HBVDNA 替比夫定 恩替卡韦 |
Application of telbivudine and entecavir in the treatment of patients with HBeAg-positive chronic hepatitis B |
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| XU Hexiang,YU Yaxin,ZHANG Mingxia,et al.. Application of telbivudine and entecavir in the treatment of patients with HBeAg-positive chronic hepatitis B[J]. Journal of Clinical Hepatology, 2011, 14(4): 265-267. DOI: 10.3969/j.issn.1672-5069.2011.04.009 |
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| Authors: | XU Hexiang YU Yaxin ZHANG Mingxia et al. |
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| Affiliation: | XU Hexiang,YU Yaxin,ZHANG Mingxia,et al.Department of Infectious Diseases,Affiliated Hospital to Xuzhou Medical College,Xuzhou 221002,China |
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| Abstract: | Objective To evaluate the efficacy and safety of telbivudine and entecavir in the treatments of patients with HBeAg-positive chronic hepatitis B(CHB).Methods Sixty HBeAg-positive CHB patients were divided into telbivudine-and entecavir-treated group.The efficacy and safety of the two groups were assessed at 12 and 24 weeks.Results There were no significant differences in the rates of normalization of ALT and of HBV DNA undetectable between the two groups at week 12 and 24(P>0.05);the loss and seroconversion... |
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| Keywords: | HBeAg HBV DNA |
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