| 乳腺癌组织中COX-2表达及临床意义的Meta分析 |
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| 引用本文： | 李蔓,鞠丽荣,许丽娜. 乳腺癌组织中COX-2表达及临床意义的Meta分析[J]. 中国循证医学杂志, 2011, 11(5): 524-528 |
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| 作者姓名： | 李蔓 鞠丽荣 许丽娜 |
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| 作者单位： | 1. 首都医科大学公共卫生与家庭医学学院,北京,100069
2. 北京市海淀区疾病预防控制中心,北京,100094 |
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| 摘 要： | 目的系统评价国内有关乳腺癌组织中COX-2表达及临床意义的研究。方法计算机检索CBM、CNKI、VIP和万方数据库,并辅以文献追溯的方法,收集公开发表的所有关于乳腺癌组织中COX-2表达及其与临床病理特征关系的病例对照研究。检索年限均为从建库至2010年7月25日。按纳入排除标准筛选文献并评价纳入研究质量后,应用RevMan 4.2.10软件进行Meta分析。结果共纳入8个病例对照研究,其中乳腺癌500例,正常乳腺153例。Meta分析结果显示:COX-2在乳腺癌组与正常乳腺对照组[OR=16.36,95%CI(9.18,29.15)]、乳腺癌高分化组与中低分化组[OR=0.34,95%CI(0.18,0.63)]的表达差异均有统计学意义;COX-2在乳腺癌淋巴结转移组与非淋巴结转移组[OR=1.36,95%CI(0.61,3.03)]、临床Ⅰ～Ⅱ期组与临床Ⅲ～Ⅳ期组[OR=0.61,95%CI(0.34,1.10)]的表达差异则无统计学意义。结论目前国内证据证明,COX-2可能参与了乳腺癌发生、发展的全过程,但尚不能作为判定乳腺癌预后的独立因素,有待于进一步深入探讨。
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| 关 键 词： | COX-2表达 乳腺癌 系统评价 Meta分析 病例对照研究 |
Expression and Clinical Significance of Cyclooxygenase-2 in Breast Cancer: A Meta-analysis |
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| LI Man,JU Li-rong,XU Li-na. Expression and Clinical Significance of Cyclooxygenase-2 in Breast Cancer: A Meta-analysis[J]. Chinese Journal of Evidence-based Medicine, 2011, 11(5): 524-528 |
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| Authors: | LI Man JU Li-rong XU Li-na |
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| Affiliation: | LI Man1*,JU Li-rong1,XU Li-na2 1.School of Public Health and Family Medicine,Capital Medical University,Beijing 100069,China,2.Haidian District Center for Disease Prevention and Control,Beijing 100094 |
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| Abstract: | Objective To investigate the expression and clinical significance of cyclooxygenase-2(COX-2) in human breast cancer with meta-analyses.Methods The published studies were searched in the CBM,CNKI,VIP and WanFang databases,and other relevant journals were also handsearched to identify all the relevant case-control trials.The quality of the included studies was assessed.The Cochrane Collaboration's software RevMan 4.2.10 was used to test the heterogeneity,overall effect and publication bias of the combined stu... |
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| Keywords: | Cyclooxygenase-2 expression Breast cancer Systematic review Meta-analysis Case-control study |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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