| 糖尿病患者罹患结直肠癌危险性的Meta分析 |
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| 引用本文： | 邵琦,任颖,赵催春,汪红平.糖尿病患者罹患结直肠癌危险性的Meta分析[J].中国循证医学杂志,2011,11(5):518-523. |
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| 作者姓名： | 邵琦 任颖 赵催春 汪红平 |
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| 作者单位： | 上海交通大学附属第六人民医院特需医疗科,上海市糖尿病临床医学中心,上海200233 |
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| 摘 要： | 目的系统评价糖尿病与结直肠癌发生率的相关性,以期为糖尿病患者结直肠癌的早期筛查提供较为客观的依据。方法计算机检索MEDLINE和EMbase,检索时限为1990年1月至2010年7月,查找糖尿病患者发生结直肠癌风险性的相关队列研究,按照纳入排除标准进行文献筛选、资料提取和质量评价后,采用RevMan 4.3软件进行Meta分析。结果共纳入17项研究,包括1 690 869例研究对象。Meta分析结果显示:糖尿病患者结直肠癌发生率较对照组高,差异有统计学意义16.50‰vs.10.13‰;OR=1.43,95%CI(1.29,1.60)]。亚组分析显示,无论男性和女性糖尿病患者,其患结直肠癌危险性均较对照组高;男性糖尿病患者风险稍高于女性(OR:1.47 vs.1.41)。结论糖尿病是结直肠癌发生的危险因素之一。
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| 关 键 词： | 糖尿病 结直肠癌 队列研究 Meta分析 |
Relationship between Diabetes Mellitus and Risk of Colorectal Cancer: A Meta-analysis |
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| SHAO Qi,REN Ying,ZHAO Cui-chun,WANG Hong-ping.Relationship between Diabetes Mellitus and Risk of Colorectal Cancer: A Meta-analysis[J].Chinese Journal of Evidence-based Medicine,2011,11(5):518-523. |
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| Authors: | SHAO Qi REN Ying ZHAO Cui-chun WANG Hong-ping |
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| Institution: | SHAO Qi,REN Ying*,ZHAO Cui-chun,WANG Hong-ping Department of Internal Medical Ward,Shanghai Clinical Center for Diabetes,The Sixth People's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200233,China |
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| Abstract: | Objective To systematically review the correlation between diabetes and the incidence rate of colorectal cancer,so as to provide objective proof for early screening diabetic patients with colorectal cancer.Methods The databases such as MEDLINE and EMbase published from January 1990 to July 2010 were searched to include cohort studies.The meta-analysis including seventeen qualified studies was performed by using the Cochrane Collaboration's RevMan 4.3 software.Results The results of meta-analyses of 17 cohor... |
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| Keywords: | Diabetes mellitus Colorectal cancer Cohort study Meta-analysis |
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