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Dimeric bis (heptyl)‐Cognitin Blocks Alzheimer's β‐Amyloid Neurotoxicity Via the Inhibition of Aβ Fibrils Formation and Disaggregation of Preformed Fibrils
Authors:Sheng‐Quan Hu  Rui Wang  Wei Cui  Shing‐Hung Mak  Gang Li  Yuan‐Jia Hu  Ming‐Yuen Lee  Yuan‐Ping Pang  Yi‐Fan Han
Institution:1. Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China;2. The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China;3. Department of Pharmaceutical Science, School of Pharmacy, Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, Shanghai, China;4. National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, China;5. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China;6. Computer‐Aided Molecular Design Laboratory, Mayo Clinic, Rochester, MN, USA
Abstract:
Keywords:Alzheimer's disease    fibrils  Bis (heptyl)‐cognitin  Morris water maze  Reactive oxygen stress  Thioflavin T
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