Toward oligosaccharide- and glycopeptide-based HIV vaccines |
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Authors: | Wang Lai-Xi |
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Affiliation: | University of Maryland Biotechnology Institute, Institute of Human Virology, Baltimore 21201, USA. wangx@umbi.umd.edu |
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Abstract: | The human immunodeficiency virus (HIV) is the causative agent of acquired immune deficiency syndrome (AIDS), and HIV type 1 (HIV-1) is responsible for the current global pandemic of HIV and AIDS. There is widespread agreement that the best hope to contain this pandemic is the development of an effective HIV-1 vaccine. The major difficulty in HIV vaccine design, however, is in identifying novel epitopes for inducing broadly neutralizing antibodies. Accumulating data have implied that the HIV-1 carbohydrates, which are a strong defense against host immune attack, can also serve as targets for vaccines. This notion was reinforced by the characterization of a novel oligomannose cluster on HIV-1 glycoprotein gp120 as the epitope of the broadly neutralizing antibody 2G12. This review describes the current status and prospective of the progress toward a carbohydrate-based HIV vaccine. Recent research on the design, synthesis and antigenicity of HIV-1 oligosaccharides and glycopeptide immunogens is also discussed. |
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