Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis |
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| Authors: | Hoff Donald R Caraway Megan L Brooks Elizabeth J Driver Emily R Ryan Gavin J Peloquin Charles A Orme Ian M Basaraba Randall J Lenaerts Anne J |
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| Affiliation: | Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA. |
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| Abstract: | Metronidazole, which is used for the treatment of infections caused by anaerobic organisms, was evaluated in Mycobacterium tuberculosis-infected guinea pigs. M. tuberculosis can adapt to hypoxia, which is present in the primary lesions of infected guinea pigs. Metronidazole treatment (for 6 weeks at 100 mg/kg of body weight) resulted in no reduction in the bacillary burden and significantly worsened lesion inflammation. |
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