褪黑素对老年人情绪障碍调节作用的临床研究

目的 研究褪黑素（改善睡眠药）对有睡眠障碍及患有轻度心脑血管病的老年人焦虑、抑郁状态的影响.方法 用多中心随机双盲和安慰剂平行对照试验设计,224例60岁以上亚健康和非急性期心脑血管病患者随机分为2组,试验组口服褪黑素3～6 mg;对照组口服安慰剂,均连服24周.用焦虑和抑郁自评量表（SAS,SDS）进行评分.结果 服用褪黑素1,3,6个月后,SAS、SDS评分均值均下降,与对照组比较有统计学显著性差异（P＜0.05～0.0001）;6个月时,焦虑情绪减少的有效率为69.4%,抑郁情绪改善的有效率为67.6%.结论 褪黑素能明显改善老年人焦虑和抑郁情绪.

Clinical trial of regulate effects of melatonin on elderly mood disfunction

Objective To study the influence of melatonin (MT) on elderly persons with mood dysfunction of anxiety and depression. Me- thods Two hundreds twenty-four aged 60~79 years cases of sub-health and the patients with non- acute stage cardiac and/or cerebral vascular diseases were carried on the multicenter, randomized , double blinded and placebo paralleled comparison clinical trial,115 cases in melatonin while 109 cases in placebo group.The patients received ether MT(3~6 mg once daily) or starch for 24weeks.At the time 0,4,12,24 weeks after treatment, the receivers filled out the self-rating depression scale (SDS) and self-rating anxiety scale (SAS) scores.Results The average scores of SAS and SDS in the MT group from 0 week to 4, 12, 24 weeks, gradually decreased, which compared with the values of the placebo group , having the statistical significant differences (P <0.05 ~ 0.0001). The effectiveness of anxious mood reduction was 69.4% in 24 weeks after taking MT, when the despondent mood improvement effectiveness is 67.6 %.Conclusion Senior citizens taking MT have remarkably improved their anxious and despondent mood.