Effect of dietary restriction upon the age-associated decline of lymphocyte DNA repair activity in mice |
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Authors: | Federico Licastro Richard Weindruch L. Jane Davis Roy L. Walford |
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Affiliation: | (1) Dipartimento di Patologia Sperimentale, Universita of Bologna, Via S. Giacomo, 14, 40126 Bologna, Italy;(2) Department of Pathology, UCLA School of Medicine, Los Angeles, California 90024, USA |
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Abstract: | Effects of dietary restriction (DR) on DNA repair capacity of mouse splenocytes after ultraviolet (UV)-induced damage were assessed. Two mouse cohorts received restricted amounts of purified hypocaloric diets; one was minimally restricted (∼75% of the caloric intake of mice fed a commercial diet ad libitum), the other was severely restricted (∼50% caloric restriction). An inverse correlation between age and DNA repair was present in the two cohorts; however, the regression lines of the two cohorts showed different slopes. DR appears to decelerate the age-associated decline of DNA repair capacity, and this delay might account in part for the improved immune function shown by old mice on DR. |
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