| 低分子铬结合物对人外周血淋巴细胞染色体畸变及姐妹染色单体互换的影响 |
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| 引用本文： | 吴国用,崔山田,李莲姬,沈美善,韩春姬.低分子铬结合物对人外周血淋巴细胞染色体畸变及姐妹染色单体互换的影响[J].延边医学院学报,1988(3). |
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| 作者姓名： | 吴国用 崔山田 李莲姬 沈美善 韩春姬 |
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| 作者单位： | 延边医学院卫生学教研室，延边医学院卫生学教研室，延边医学院卫生学教研室，延边医学院卫生学教研室，延边医学院卫生学教研室 |
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| 摘 要： | 本文研究了低分子铬结合物对人外周血淋巴细胞染色体畸变及姐妹染色单体互换的影响。六价铬(K_2Cr_2O_7和CrO_3)实验组的染色体畸变率明显高于对照组,但是三价铬和低分子铬结合物实验组的染色体畸变率与对照组无明显差异。六价铬和三价铬实验组每细胞姐妹染色单体互换平均数明显高于对照组,但是低分子铬结合物实验组与对照组之间无明显差异。
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| 关 键 词： | 染色体畸变 姐妹染色单体互换 铬 |
Frequency of Chromosome Aberration and Sister-Chromatid Exchange in Cultured Human Lymphocytes to Low Molecular Weight Chromium-Binding Substance |
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| Wu Guoyong.Frequency of Chromosome Aberration and Sister-Chromatid Exchange in Cultured Human Lymphocytes to Low Molecular Weight Chromium-Binding Substance[J].Journal of Medical Science Yanbian University,1988(3). |
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| Authors: | Wu Guoyong |
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| Institution: | Department of Hygiene |
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| Abstract: | The frequency of chromosome aberration and sister-chromatid exchange in the peripheral blood lymphocyte to low molecular weight chromiumbinding substance(LMWCr)was studied. The frequencies of chromosome aberration in the human peripheral blood lymphocyte to hexavalent chromium(K_2Cr_2O_7 and CrO_3)were significantly higher than in the control, but not trivalent chromium(CrCl_3)and LMWCr. The frequency of sister-chromatid exchange in the peripheral blood lymphocyte to hexavalent and trivalent chromium was remarkably higher than that of control,but not LMWCr. |
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| Keywords: | chromosome aberration sister-chromatid exchange chromium |
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