膜分离技术分离提纯蝙蝠蛾被毛孢菌丝体水提液

目的探讨膜分离技术在中药水提液分离、提纯中的应用。方法以蝙蝠蛾被毛孢菌丝体水提液为对象，考察陶瓷膜的适配性与工艺参数，并与传统的水提醇沉技术对比。结果膜分离技术的最佳膜孔径为0．2μm，小试试验（日处理量30L）需配置膜面积0．3m^2，中试试验（日处理量200L）需配置膜面积2．0m^2；中药与药液比为1：15，工作压力为0．2MPa，温度为80℃。经成品综合考察，膜分离技术优于醇沉技术。结论膜分离技术优于醇沉技术，有可能在大生产中取代醇沉技术。

Study on Separation and Purification for Water Extraction Solution of Cordyceps Cephalosporium Mycelia by Membrane Separation Technique

Objective To study the application of membrane separation technique in the separation and purification of water extraction solution in the Chinese crude drug. Methods The water extraction solution of cordyceps cephalosporium mycelia was separated and purified. The adaptation and technological parameters of ceramic membrane were investigated and compared with the traditional technique of water extraction and alcohol precipitation. Results The technological parameters of membrane separation technique were as follows： the optimal membrane aperture 0. 2 μm, the configured membrane area was 0. 3 m^2 for the daily treated capacity of 30 L in small test and 2. 0 m^2 the daily treated capacity of 200 L in pilot test. The ratio of the Chinese crude drug and medicinal solution was 1 ： 15 with the working pressure of 0. 2 MPa and the temperature of 80℃. Based on the comprehensive investigation for the finished product, the membrane separation technique was superior to the alcohol precipitation technique. Conclusion The membrane separation technique is better than the alcohol precipitation technique and can replace the alcohol precipitation technique in large-scale industrial production.