| Ph1染色体及bcr/abl融合基因检测在慢性粒细胞白血病中的诊断意义 |
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| 引用本文： | 曹友德,徐伟,肖佩玲,石詠中,聂盛丹,付冀辉.Ph1染色体及bcr/abl融合基因检测在慢性粒细胞白血病中的诊断意义[J].中国现代医学杂志,2008,18(23):3520-3522. |
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| 作者姓名： | 曹友德 徐伟 肖佩玲 石詠中 聂盛丹 付冀辉 |
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| 作者单位： | 1. 湖南省人民医院临床医学研究所,湖南,长沙,410005
2. 湖南省人民医院血液科,湖南,长沙,410005 |
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| 摘 要： | 目的 探讨Ph1染色体和bcr/abl融合基因检测在慢性粒细胞白血病诊断中的意义.方法 选择28例慢性粒细胞白血病患者和20例缺铁性贫血患者作为研究对象,采用骨髓细胞短期培养法制备染色体、采用RT-PCR法分析bcr/abl融合基因.结果 28例慢性粒细胞白血病患者中,Ph1染色体阳性者25例(89.3%),bcr/abl阳性者26例(92.9%),Ph1和bcr/abl均阳性25例(89.3%),Ph1阴性、bcr/abl阳性1例(3.6%),Ph1和bcr/abl均阴性2例(7.1%).20例缺铁性贫血患者Ph1和bcr/abl均阴性.结论 Ph1染色体、bcr/abl融合基因的检测有助于慢性粒细胞白血病的诊断和鉴别诊断.
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| 关 键 词： | 白血病 Ph1染色体 bcr/abl融合基因 |
Significance of detection of Ph1 chromosome and bcr/abl fusion gene in chronic myelocytic leukemia |
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| CAO You-de
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XU Wei
,
XIAO Pei-ling
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SHI Yong-zhong
,
NIE Sheng-dan
,
FU Ji-hui.Significance of detection of Ph1 chromosome and bcr/abl fusion gene in chronic myelocytic leukemia[J].China Journal of Modern Medicine,2008,18(23):3520-3522. |
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| Authors: | CAO You-de XU Wei XIAO Pei-ling SHI Yong-zhong NIE Sheng-dan FU Ji-hui |
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| Abstract: | ObjectiveTo explore the clinical significance of detection of Ph1 chromosome and bcr/abl fusion gene in the diagnosis for chronic myelocytic leukemia(CML) . MethodsTwenty-eight patients with chronic myelocytic leukemia and twenty patients with iron deficiency anemia were selected. Bone marrow short-term culture was used to prepare the chromosome,bcr/abl fusion gene was analyzed by RT-PCR method. ResultsIn 28 patients with chronic myelocytic leukemia,25(89.3%) cases were Ph1 Chromosome positive,26(92.9%) cas... |
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| Keywords: | leukemia ph1chromosome bcr/abl fusion gene |
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