围绝经期抑郁症妇女性激素水平的变化

目的:通过围绝经期抑郁症妇女治疗前后性激素水平变化情况的比较和分析,探讨围绝经期抑郁症妇女性激素生理功能的改变。方法:采用自评抑郁量表(self-rating depression scale,SDS)抑郁状态问卷(depression status inventory,DSI)对年龄在40~54周岁的围绝经期门诊就诊妇女进行抑郁症状的评估;采用化学发光法对围绝经期抑郁症治疗前的、治疗后显著好转的、围绝经期正常的以及正常生育年龄的妇女进行血清4项性激素水平测定。结果:围绝经期抑郁症组妇女的血清E2、FSH、LH、P水平与生育年龄组、围绝经期正常组差异均有统计学意义(均P<0.01);围绝经期抑郁症治疗6个月后症状有显著好转妇女的血清性激素水平变化情况:血清E2、P水平与治疗前比较有显著升高,血清FSH、LH水平与治疗前比较有显著降低,且血清E2、FSH、LH、P水平与围绝经期正常组比较差异无统计学意义(P>0.05)。结论:围绝经期妇女的血清E2、P水平显著降低,血清FSH、LH水平显著升高,性激素的生理和调节功能变化,性腺轴系调节功能失调,导致机体内分泌功能紊乱,是围绝经期妇女发生抑郁症的重要病因。

Change of sex hormone levels in perimenopause women with depression

Objective：To investigate the changes of physiological functions in perimenopausal women with depression via comparing and analyzing the changes of sex hormone levels before and after treatment.Methods：Perimenopausal patients with the age of 40 to 54 yrs from the outpatient clinc were assessesed by Self-Rating Depression Scale（SDS）and Depression Status Inventory（DSI）.Four kinds of serum sex hormone level of perimenopausal women with depression,women with symptom improvement after treatment,normal women in perimenopausal period and normalwomen in reproductive age were tested by chemiluminescence method.Results：Singificant difference were showed in serum E2,FSH,LH,P among the group of perimenopausal women with depression,normal women in reproductive age group,normal perimenopausal group（P 0.01）.6 months later after treatment,Serum level of E2,P were significantly higher,while FSH,LH levels were significantly decreased.Compared with normal permenopausal group,E2,FSH,LH,P levels all showed no statistically significant difference（P 0.05）.Conclusions：Endocrine disorder was caused by decreas of E2 and P,increase of FSH and LH,and sex hormone dysfunction,which is important factor leading to depression for perimenopausal women.