Biochemical alterations in paromomycin-treated Leishmania donovani promastigotes |
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| Authors: | M. Maarouf Françoise Lawrence Spencer Brown M. Robert-Gero |
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| Affiliation: | (1) Institut de Chimie des Substances Naturelles, C.N.R.S., F-91198 Gif-sur-Yvette Cedex, France Tel.: 33 (1) 69-82-30-37; Fax: 33 (1) 69-82-72-47, FR;(2) Service de Cytométrie, Institut des Sciences Végétales, Avenue de la Terrasse, Gif-sur-Yvette, France, FR |
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| Abstract: | Paromomycin is used for the treatment of leishmaniasis in humans, but little is known about its mechanism of action. Investigating the effect of this antibiotic on promastigotes of Leishmania donovani, we showed that inhibition of the multiplication of these parasites could be related to its effect on RNA synthesis and to modifications of membranous polar lipids and membrane fluidity, leading to altered membrane permeability. Received: 13 June 1996 / Accepted: 11 September 1996 |
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