Effect of calcitonin on total body bone mineral contents of experimental osteoporotic rats determined by dual photon absorptiometry |
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Authors: | Kiyoshi Nakatsuka Yoshiki Nishizawa Satoshi Hagiwara Hidenori Koyama Takami Miki Hironobu Ochi Hirotoshi Morii |
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Institution: | (1) Second Department of Internal Medicine, Osaka City University Medical School, Asahi-machi, Abeno-ku, 545 Osaka, Japan;(2) Department of Radiology, Osaka City University Medical School, Asahi-machi, Abeno-ku, 545 Osaka, Japan |
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Abstract: | Summary Total body bone mineral (TBBM) content in rats was measured by dual photon absorptiometry (DPA). TBBM showed significant increases
over 4 weeks in control groups with significant bone loss over the same time in prednisolone-injected rats on low calcium
feed. Daily injections of calcitonin significantly reduced loss of bone mass. Both prednisolone- and prednisolone-calcitonin-injected
groups showed significantly elevated serum alkaline phosphatase with the prednisolone-calcitonin group also exhibiting elevated
serum calcium and phosphate levels, confirming the impact of the experimental protocol. TBBM measured by DPA in all groups
correlated well (r=0.928,P<0.001 n=20) with the total ash weight suggesting that the method reflects total skeletal mineral content in the small animal.
TBBM measurement by DPA proves well-suited to monitoring bone mineral in a small animal experimental setting. |
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Keywords: | Dual photon absorptiometry Bone mineral Rat Ash weight Calcitonin |
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