Collision Tumors of the Sella: Craniopharyngioma and Silent Pituitary Adenoma Subtype 3: Case Report |
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| Authors: | Olga Moshkin Bernd W Scheithauer Luis V Syro Alejandro Velasquez Eva Horvath Kalman Kovacs |
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| Institution: | (1) Department of Laboratory Medicine, St. Michael’s Hospital, University of Toronto, 30 Bond Street, 2 Cardinal Carter Wing, Toronto, ON, Canada, M5B 1W8;(2) Department of Pathology, Mayo Clinic, Rochester, MN, USA;(3) Division of Neurosurgery, Hospital Pablo Tobon Uribe and Clinical Medellin, Medellin, Colombia;(4) Pediatric Endocrinology, Hospital Pablo Tobon Uribe, Medellin, Colombia |
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| Abstract: | Collision tumors of the sella turcica are rare and consist mainly of more than one type of pituitary adenoma, usually a corticotropin-
and a prolactin-producing adenoma. The association of a craniopharyngioma and a pituitary adenoma is rare. Herein, we report
the first case of an association between craniopharyngioma and silent pituitary adenoma subtype 3. It involved a 12-year-old
boy who underwent a frontal craniotomy with surgical removal of a calcified sellar tumor. Histology revealed an adamantinomatous
craniopharyngioma; however, by electron microscopy, there was conclusive evidence of adenoma cells showing the ultrastructural
features of silent pituitary adenoma subtype 3. Endocrine and neuroimaging as well as detailed immunohistochemical and ultrastructural
studies were undertaken. The literature is also reviewed. |
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| Keywords: | sella turcica collision tumors craniopharyngioma silent pituitary adenoma subtype 3 |
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