肝硬化合并自发性腹膜炎优势菌及耐药分析

目的 探讨肝硬化合并自发性细菌性腹膜炎(SBP)患者腹水感染的优势菌分布及其抗菌药物的敏感性,为临床诊断和合理用药提供可靠的依据.方法 以我院2004年3月至2009年3月诊断为肝硬化合并SBP腹水细菌培养结果阳性的84例住院患者为研究对象,对86株病原菌进行鉴定和药敏分析.结果 腹水中病原菌以大肠埃希菌检出率最高,占48.8%;其次是阴沟肠杆菌和肺炎克雷伯菌.革兰阴性杆菌对第三代头胞菌素耐药性较低,而大肠埃希菌对亚胺培南耐药率为零.结论 对SBP应加强病原菌的检测和药敏试验,并依据药敏结果合理选用抗菌药物.

Analysis on predominating strains of bacteria and drug sensitivity in liver cirrhosis patients combined with spontaneous bacterial peritonitis

Objective To investigate the distribution of the pathogens of spontaneous bacterial peritonitis (SBP)and their drug resistance, and to guide the selection of reasonable antibiotics in clinic. Metlols 84 cases of hospitalized cirrhotic patients with SBP were admitted to our hospital between March 2004 and March 2009. Ascitic fluids of all cases were cultured. The total 84 strains of pathogens were identified and the drug resistance was analyzed. Results Among the pathogens in the ascetic fluids,ratio of Escherichia coli was the top (48.8%), the next were Enterobacter aerogenes and Klebsiella pneumoniae. The drug resistance of gram negative bacilli to the third generation cepho was lower, and E. colito imipenem was zero. Concluslions Pathogen detections and drug sensitivity tests to SBP should be emphased and the effective antibiotics could be selected and resistant bacteria could be reduced.