Mechanism of ulcerogenic activity of indomethacin and oxyphenbutazone

K.P. BHARGAVA, M.B. GUPTA and K.K. TANGRI, tMechanism of ulcerogenic activity of indomethacin and oxyphenbutazone, European J. Pharmacol. 22 (1973) 191–195.The ulcerogenic activity of indomethacin and oxyphenbutazone in albino rats was dose dependent. The gastric ulcers produced by indomethacin and oxyphenbutazone were significantly reduced by pretreatment with phenoxy-benzamine, phentolamine and by prior bilateral adrenalectomy and spinal cord transection while imipramine pre-treatment potentiated their incidence. Mepyramine prevented the ulcerogenic activity of oxyphenbutazone but failed to prevent the ulcers produced by indomethacin. Pretreatment with 2-bromolysergic acid diethylamide (BOL-148). propranolol and atropine failed to protect the animals from the ulcerogenic activity of indomethacin and oxyphenbutazone. The mechanism of ulcerogenic activity of these compounds is discussed.