| 小鼠日本血吸虫模型肝组织坏死形态学观察 |
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| 引用本文： | 冯振卿,李玉华.小鼠日本血吸虫模型肝组织坏死形态学观察[J].南京医科大学学报,1997,17(4):313-314. |
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| 作者姓名： | 冯振卿 李玉华 |
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| 作者单位： | 南京医科大学寄生虫学教研室 |
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| 基金项目： | 江苏省教委自然科学基金 |
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| 摘 要： | 建立小鼠日本血吸虫肝虫卵肉芽肿模型和自然感染模型，发现早期肝脏出现，片状或灶性凝固性坏死，后期发生纤维组织增生。提示肝组织凝固性坏死诱发肝纤维化，与虫卵肉芽肿引起的纤维化协同作用可能是血吸虫性肝硬化的又一发生机理。
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| 关 键 词： | 日本血吸虫 动物模型 凝固性 小鼠 肝组织坏死 |
Morphological Study on Liver Tissue Necrosis of Animal Models of Schistosoma Japonicum in Mice |
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| Feng Zhenqing,Li Yuhua ,Qiu Zhenning,et al.Morphological Study on Liver Tissue Necrosis of Animal Models of Schistosoma Japonicum in Mice[J].Acta Universitatis Medicinalis Nanjing,1997,17(4):313-314. |
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| Authors: | Feng Zhenqing Li Yuhua Qiu Zhenning |
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| Institution: | Feng Zhenqing,Li Yuhua *,Qiu Zhenning,et al Department of Parasitology,*Department of Pathology,Nanjing Medical University,Nanjing\ 210029 |
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| Abstract: | Experimental models of hepatic Schistosoma japonicum egg granuloma and mice infected with cercarie of Schistosoma japonicum in abdominal skin were established in this study. The massive and focal coagulation necrosis of liver was found in early stage and proliferation of fibrous tissue was developed in late stage. The results suggest that the coagulation necrosis of liver tissue induce hepatic fibrosis. The coordinative effect of hepatic fibrosis induced by coagulation necrosis and by egg granuloma might be another pathogenesis of cirrhosis caused by Schistosoma japonicum. |
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| Keywords: | Schistosoma japonicum animal model necrosis coagulation mice |
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