急性脑出血患者B型利钠肽浓度变化及临床意义

目的 观察急性脑出血患者血浆B型利钠肽(BNP)浓度变化,初步探讨BNP在急性脑出血患者中的临床意义.方法 应用微粒子酶免分析 (MEIA)方法测定100例脑出血患者入院第2天BNP浓度,计算其脑出血量,在入院第1、3、7、15天进行格拉斯哥(GCS)评分、美国国立卫生院脑卒中患者神经功能缺损评分量表(NIHSS)评分,在出院或者死亡时进行格拉斯哥预后(GOS)评分.结果 脑出血患者入院第2天BNP浓度与脑出血量呈正相关(r=0.367,P=0.000),与入院第1、3、7、15天GCS评分呈负相关(r值分别为-0.553、-0.429、-0.473、-0.501,均P=0.000),与入院第1、3、7、15天NIHSS评分呈正相关(r值分别为0.491、0.444、0.427、0.458,均P=0.000),与GOS评分呈正相关(r=0.507,P=0.000).结论 血浆BNP浓度能有效预测脑出血预后,可能为判断患者病情危重程度提供新的思路.

Abstract：

Objective To observe the change and its clinical significance of serum B-type brain natriuretic peptide (BNP) concentration in patients with acute cerebral hemorrhage. Methods The plasma BNP level was measured by microparticle enzyme immunosorbent assay (MEIA) method in 100 patients with acute cerebral hemorrhage. The blood volume of cerebral hemorrhage was computed respectively. The Glasgow Coma Scale (GCS) and National Institutes of Health Stroke Scale (NIHSS) were used to evaluate nerve function on the 1st, 3rd, 7th and 15th day after admission, and the Glasgow Out-come Scale (GOS) was used when the patient was discharged from hospital or died. Results The plasma BNP level at the 2nd day after admission was positively correlated with the blood volume of cerebral hemorrhage in patients with acute cerebral hemorrhage (r=0.367, P=0.000), with NIHSS score at the 1st, 3rd, 7th and 15th after admission (r=0.491, 0.444, 0.427 and 0.458, all P=0.000), and with GOS score (r=0.507, P=0.000). In addition, it was negatively correlated with GCS score at the 1st, 3rd, 7th and 15th after admission (r=-0.553, -0.429, -0.473 and -0.501, all P=0.000). Conclusions The plasma level of BNP is good for predicting the strike of cerebral hemorrhage patient′s condition, it is likely to provide a original thread for judge the severe degree of patient′s condition.

The changes and the corresponding clinical significance of serum B-type brain natriuretic peptide concentration in patients with acute cerebral hemorrhage

Objective To observe the change and its clinical significance of serum B-type brain natriuretic peptide (BNP) concentration in patients with acute cerebral hemorrhage. Methods The plasma BNP level was measured by microparticle enzyme immunosorbent assay (MEIA) method in 100 patients with acute cerebral hemorrhage. The blood volume of cerebral hemorrhage was computed respectively. The Glasgow Coma Scale (GCS) and National Institutes of Health Stroke Scale (NIHSS) were used to evaluate nerve function on the 1st, 3rd, 7th and 15th day after admission, and the Glasgow Out-come Scale (GOS) was used when the patient was discharged from hospital or died. Results The plasma BNP level at the 2nd day after admission was positively correlated with the blood volume of cerebral hemorrhage in patients with acute cerebral hemorrhage (r=0.367, P=0.000), with NIHSS score at the 1st, 3rd, 7th and 15th after admission (r=0.491, 0.444, 0.427 and 0.458, all P=0.000), and with GOS score (r=0.507, P=0.000). In addition, it was negatively correlated with GCS score at the 1st, 3rd, 7th and 15th after admission (r=-0.553, -0.429, -0.473 and -0.501, all P=0.000). Conclusions The plasma level of BNP is good for predicting the strike of cerebral hemorrhage patient′s condition, it is likely to provide a original thread for judge the severe degree of patient′s condition.