| 非小细胞肺癌组织COX-2和VEGF-C及C-erbB-2的表达与淋巴结转移的关系 |
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| 引用本文： | 王彦威,郑瑞锋,闫敏,百红灿,徐建林.非小细胞肺癌组织COX-2和VEGF-C及C-erbB-2的表达与淋巴结转移的关系[J].中国肿瘤临床与康复,2007,14(4):306-308. |
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| 作者姓名： | 王彦威 郑瑞锋 闫敏 百红灿 徐建林 |
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| 作者单位： | 武警河南总队医院,郑州,450052 |
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| 摘 要： | 目的研究COX-2、VEGF-C、C-erbB-2在非小细胞肺癌(NSCLC)组织中的表达及与淋巴结转移的关系。方法采用免疫组化方法检测52例非小细胞肺癌组织中COX-2、VEGF-C及C-erbB-2的表达水平,结合临床资料进行分析。结果52例肺癌中,COX-2阳性34例(65.4%),VEGF-C阳性33例(63.4%),C-erbB-2阳性35例(67.3%)。COX-2、VEGF-C、C-erbB-2的表达与临床分期、淋巴结转移呈正相关;COX-2、VEGF-C、C-erbB-2之间的表达呈正相关。结论COX-2、VEGF-C、C-erbB-2的表达呈正相关,它们可能在基因水平相互调控;COX-2、VEGF-C及C-erbB-2在NSCLC中的高表达,与肿瘤的发展、淋巴结转移有密切的联系。
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| 关 键 词： | 肺肿瘤 淋巴结转移 |
| 文章编号： | 1005-8664(2007)04-0306-03 |
| 修稿时间： | 2006年9月14日 |
Expression of COX-2, VEGF-C and C-erbB-2 in non-small cell lung cancer and their correlations with lymph node metastasis |
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| WANG Yan-wei,ZHENG Rui-feng,YAN Min,et al.Expression of COX-2, VEGF-C and C-erbB-2 in non-small cell lung cancer and their correlations with lymph node metastasis[J].Chinese Journal of Clinical Oncology and Rehabilitation,2007,14(4):306-308. |
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| Authors: | WANG Yan-wei ZHENG Rui-feng YAN Min |
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| Abstract: | Objective To investigate the expression of COX-2,VEGF-C and C-erbB-2 in non-small cell lung cancer and their correlations with lymph node metastasis.Methods The expression of COX-2,VEGF-C and C-erbB-2 in 52 cases of non-small cell lung cancer were detected by immunohistochemical method,and their correlations with lymph node metastasis were analyzed.Results In the 52 cases,the positive rates of COX-2,VEGF-C and C-erbB-2 were 65.4%,63.4% and 67.3% respectively.The expression of COX-2,VEGF-C and C-erbB-2 positively correlated with tumor stages and lymph node metastasis.The expression of COX-2,VEGF-C and C-erbB-2 positively correlated with each other.Conclusion COX-2,VEGF-C and C-erbB-2 may condition each other at gene level.The high expression of COX-2,VEGF-C and C-erbB-2 is associated with progression and metastasis of lung cancer. |
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| Keywords: | COX-2 VEGF-3 C-erbB-2 |
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