Aberrant CD45 (Leukocyte Common Antigen) Staining of Non-Malignant Breast Lesions in Zinc Formalin Fixed Tissue

Abstract

Leukocyte common antigen (LCA/T200/CD45) has been considered an antigenic epitope expressed only on the cytoplasmic surface membrane of nucleated hematopoietic cells. This study describes the expression of LCA on the surface membrane of mammary ductal cells in specimens of fibrocystic disease and fibroadenoma. The reaction appeared specific and is most likely due to unexpected antigenic epitope expression of LCA in these tissues. (The J Histotechnol 16:151, 1993)