The crystallography behavior of carbamazepine under compression pressure |
| |
Authors: | H Kala U Haack U Wenzel G Zessin P Pollandt |
| |
Affiliation: | Sektion Pharmazie, Wissenschaftsbereich Pharmazeutische Technologie, Martin-Luther-Universit?t Halle-Wittenberg. |
| |
Abstract: | In the present paper the crystallographic behavior of the carbamazepine modifications I, II and III were studied under various conditions by means of X-ray powder diffraction, IR-spectroscopy and differential-scanning-calorimetry. It was found that the crystal lattice of the carbamazepine modification I is relative stable to the applied pressure forms, whereas modification II under similar conditions undergoes a polymorphic transformation into carbamazepine modification III, the extent of which depends on compression pressure and storage time of the tablets. In the compression samples of carbamazepine modification III neither IR-spectroscopically nor X-ray-diffractionally an influence of the pressure could be found on growing up of the enantiotrophic modification I. |
| |
Keywords: | |
|
|