| 珍珠祛斑美容片的急性毒性和遗传毒性试验研究 |
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| 引用本文： | 刘冬英,梅松,付颖,来伟旗,陈建国,王茵. 珍珠祛斑美容片的急性毒性和遗传毒性试验研究[J]. 癌变．畸变．突变, 2008, 20(6): 487-489. DOI: 10.3969/j.issn.1004-616x.2008.06.019 |
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| 作者姓名： | 刘冬英 梅松 付颖 来伟旗 陈建国 王茵 |
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| 作者单位： | 浙江省医学科学院，浙江 杭州，310013 |
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| 摘 要： | 背景与目的： 研究珍珠祛斑美容片的急性毒性和遗传毒性。 材料与方法： 采用大鼠、小鼠急性毒性试验、Ames试验、小鼠骨髓嗜多染红细胞微核试验和小鼠精子畸形试验对珍珠祛斑美容片进行常规安全性实验分析。 结果： 急性毒性实验结果表明，大鼠、小鼠灌胃给予珍珠祛斑美容片，其最大耐受剂量(MTD)均大于200 g/kg。Ames试验、微核试验和精子畸形试验结果均为阴性。 结论： 在人体推荐摄入剂量，每人2.0 g/d范围内使用珍珠祛斑美容片是安全可靠的。
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| 关 键 词： | 珍珠祛斑美容片 急性毒性 Ames试验 微核试验 精子畸形试验 |
| 收稿时间： | 2008-01-15 |
| 修稿时间： | 2008-03-19 |
Acute Toxicity and Genotoxicity Tests of Pearl Anti-spot Cosmetic Slice |
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| LIU Dong-ying,MEI Song,FU Ying,LAI Wei-qi,CHEN Jian-guo,WANG Yin. Acute Toxicity and Genotoxicity Tests of Pearl Anti-spot Cosmetic Slice[J]. Carcinogenesis,Teratogenesis and Mutagenesis, 2008, 20(6): 487-489. DOI: 10.3969/j.issn.1004-616x.2008.06.019 |
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| Authors: | LIU Dong-ying MEI Song FU Ying LAI Wei-qi CHEN Jian-guo WANG Yin |
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| Affiliation: | Zhejiang Academy of Medical Science, Hangzhou 310013, China |
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| Abstract: | BACKGROUND AND AIM:To study the acute toxicity and genotoxicity of pearl anti-spot cosmetic slice.MATERIALS AND METHODS:Acute toxicity test,Ames test,micronucleus test of bone marrow PCE cell in mice,sperm abnormality test of mice were used.RESULTS:The oral acute toxicity study revealed that the maximal tolerance dose(MTD) of pearl anti-spot cosmetic slice was greater than 20.0 g/kg in mice.The results of genotoxicity tests were all negative,including Ames test,micronucleus test and sperm shape abnormality test.CONCLUSION:Pearl anti-spot cosmetic slice showed no acute toxicity and genotoxicity in this study.Thus,pearl anti-spot cosmetic slice is safe at the daily recommended dose(2.0 g/person/day). |
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| Keywords: | pearl anti-spot cosmetic slice acute toxicity Ames test micronucleus test sperm abnormality test |
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