NOD样受体蛋白3炎症小体在急性肺损伤/急性呼吸窘迫综合征中的作用机制研究进展

急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)是由多种非心源性肺内外因素引起的急性进行性呼吸衰竭,发病核心为过度放大或失控的炎症反应,目前没有特效的治疗药物.NOD样受体蛋白3(nucleotide-binding domain (NOD)-like receptor protein 3,NLRP3)炎症小体是细胞受到刺激时形成的多蛋白复合体,活化后导致细胞焦亡及IL-1β、IL-18等产生,在多种感染性、炎症性疾病中起重要作用.引起肺损伤的多种因素均可导致NLRP3炎症小体形成、活化,有研究提示,与ALI/ARDS中的过度炎症反应有关.因而深入研究NLRP3炎症小体在ALI/ARDS中的作用,对于进一步阐明ALI/ARDS的发病机制有重要意义,甚至有望成为治疗ALI/ARDS的新靶点.

The role and mechanisms of nucleotide-binding domain NOD-like receptor protein 3 inflammasome in acute lung injury/acute respiratory distress syndrome

The acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is an acute onset progressing hypoxemic respiratory failure.Overwhelming inflammatory response is involved.There is still no effective treatment strategy available.Nucleotide-binding domain (NOD)-like receptor protein 3(NLRP3) inflammasome is an oligomer of intracellular proteins that,once activated by an insult or damaging signal,induces pyroptosis and the production of IL-1β and IL-18 which mediate inflammatory response.NLRP3 inflammasome plays an important role in the infectious and inflammatory diseases and can be activated by many factors which induce ALI/ARDS.Further research on the role of NLRP3 inflammasome in ALI/ARDS is important for the clarification of the pathogenesis and treatment of ALI/ARDS.