体外冲击波对阴茎硬结症的临床疗效Meta分析

目的 系统评价体外冲击波对阴茎硬结症的临床疗效.方法 通过计算机检索2015年12月以前Pubmed、Medline、Embase数据库,纳入体外冲击波(ESWT)治疗阴茎硬结症的随机对照试验.按照纳入和排除标准进行文献筛选,用Jadad量表对纳入文献的方法学评价,并提取资料.采用Review manager 5.3软件进行Meta分析.结果 共有8篇研究被纳入,930例患者,其中ESWT组606例,对照组324例.Meta分析结果表明:与对照组相比,体外冲击波治疗组阴茎局部疼痛人数明显减少[OR=3.91,95％ CI(2.11,7.23)],白膜纤维斑块缩小人数明显减少[OR =3.18,95％ CI(2.24,4.51)],阴茎勃起后弯曲度减小的人数也减少[OR =3.18,95％CI (2.24,4.51)],性生活能力提高的人数明显增加[OR=3.38,95％ CI(1.83,6.24)].结论 体外冲击波能减轻阴茎硬结症患者的疼痛,缩小白膜斑块,改善弯曲畸形,提高性生活能力,对阴茎硬结症有一定的疗效.

Efficacy of extracorporeal shock wave therapy in the treatment of peyronie's disease: a Meta-analysis

Objectives To evaluate the efficacy of extracorporeal shock wave therapy(ESWT)in the treatment of peyronie's disease(PD).Methods PubMed,MEDLINE,EMBASE for available literatures published before December 2015 were searched.And then the treatment of penile pain,plaque size,deviation angle and intercourse function by ESWT were accessed.Results Eight studies were assessed.Compared ESWT with control for penile pain,the remission rate was higher [OR =3.91,95 ％ C I (2.11,7.23)],the pooled odds risk of reduction of plaque volume was [OR =3.18,95 ％CI (2.24,4.51)] in the ESWT group.The number of patients in reducing deviation angle of penis decreased significantly [OR =3.18,95 ％ CI (2.24,4.51)].After treatment by ESWT,intercourse functions of more patients were improved[OR =3.38,95％CI(1.83,6.24)].Conclusions ESWT could alleviate penile pain and reduce or soften PD plaque,decrease the deviation angle of penis and improve the intercourse function.